AB242194

Anti-Homeobox protein cut-like 1 antibody [CL5275]

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(4 제품이 사용된 논문 )

Mouse Monoclonal Homeobox protein cut-like 1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CUX1 aa 700 to C-terminus.

대체 명칭 보기

CUTL1, CUX1, Homeobox protein cut-like 1, CCAAT displacement protein, CDP/Cux p200, Homeobox protein cux-1, CDP

4 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Homeobox protein cut-like 1 antibody [CL5275] (AB242194)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Homeobox protein cut-like 1 antibody [CL5275] (AB242194)

Paraffin-embedded human endometrium tissue stained for Homeobox protein cut-like 1 using ab242194 at 1/1000 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-Homeobox protein cut-like 1 antibody [CL5275] (AB242194)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Homeobox protein cut-like 1 antibody [CL5275] (AB242194)

Paraformaldehyde-fixed, X-Triton-100 permeabilized SH-SY5Y (human neuroblastoma cell line from bone marrow) cells labeling Homeobox protein cut-like 1 (Green) using ab242194 at 4 μg/ml dilution in ICC/IF analysis. Microtubule probe visualized in red.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Homeobox protein cut-like 1 antibody [CL5275] (AB242194)

Paraffin-embedded human cerebellum tissue stained for Homeobox protein cut-like 1 using ab242194 at 1/1000 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Homeobox protein cut-like 1 antibody [CL5275] (AB242194)

Paraffin-embedded human cervix tissue stained for Homeobox protein cut-like 1 using ab242194 at 1/1000 dilution in immunohistochemical analysis.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

CL5275

Isotype

IgG2b

Carrier free

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CUX1 aa 700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P39880

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "2-10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

Purification 관련 사항

Purified from TCS.

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The Homeobox protein cut-like 1 often abbreviated as CUX1 functions as a transcription factor involved in the regulation of gene expression. It has an approximate mass of 110 kDa. CUX1 localizes mainly in the nucleus and is widely expressed in various tissues with higher levels observed in the thymus spleen and testis. This protein plays a significant role in cell cycle progression particularly during the S phase where it aids in DNA replication and repair.

Biological function summary

CUX1 regulates the transcription of genes involved in cell proliferation and differentiation. It forms part of a larger transcriptional complex often interacting with other transcription factors and co-regulators to exert its effects. CUX1 influences several developmental processes including hematopoiesis and neuronal differentiation highlighting its broad involvement in cellular function and development.

Pathways

CUX1 interacts within key signaling pathways such as the Wnt signaling and TGF-beta pathways. It plays a role in modulating the expression of genes controlled by these pathways impacting cell fate and proliferation. CUX1 often cooperates with other proteins such as SMADs in the TGF-beta pathway to execute complex regulatory functions. This partnership highlights the integrative role of CUX1 in cellular signaling networks that maintain homeostasis.

CUX1 has been linked to oncogenesis particularly in cancers such as breast cancer and leukemia. Alterations in CUX1 expression or function can lead to uncontrolled cell proliferation as seen in these cancers. Additionally CUX1 interacts with proteins like TP53 in cancer contexts modulating apoptosis and cellular stress responses. These interactions and effects demonstrate the pivotal involvement of CUX1 in the pathogenesis of certain diseases making it a potential target for therapeutic intervention.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.. CDP/Cux p110. Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1.

See full target information CUX1

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of virology 99:e0117324 PubMed39692477

2024

Tannic acid reactivates HIV-1 latency by mediating CBX4 degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Cancan Chen,Zhihan Zhong,Wanying Zhang,Baijin Xia,Liyang Wu,Liting Liang,Yiwen Zhang,Hui Zhang,Xu Zhang,Ting Pan,Linghua Li,Bingfeng Liu

Development (Cambridge, England) 148: PubMed34184026

2021

scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse.

Applications

Unspecified application

Species

Unspecified reactive species

Marie-Theres Wittmann,Sayako Katada,Elisabeth Sock,Philipp Kirchner,Arif B Ekici,Michael Wegner,Kinichi Nakashima,Dieter Chichung Lie,André Reis

Biochemical pharmacology 178:114050 PubMed32446887

2020

Perinatal exposure of rats to the HIV drug efavirenz affects medial prefrontal cortex cytoarchitecture.

Applications

Unspecified application

Species

Unspecified reactive species

L P Garcia,L Van de Wijer,S I Hanswijk,J Rando,J S Witteveen,A Middelman,R Ter Heine,Q de Mast,G J M Martens,A J A M van der Ven,A F A Schellekens,J R Homberg,S M Kolk

Molecular medicine reports 20:4285-4292 PubMed31545436

2019

Adenovirus vector‑mediated in vivo gene transfer of nuclear factor erythroid‑2p45‑related factor 2 promotes functional recovery following spinal cord contusion.

Applications

Unspecified application

Species

Unspecified reactive species

Feng-Chen Zhu,Dian-Ming Jiang,Ming-Hua Zhang,Bo Zhao,Chao He,Jian Yang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Homeobox protein cut-like 1 antibody [CL5275]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Homeobox protein cut-like 1 antibody [CL5275] (AB242194)

Immunocytochemistry/ Immunofluorescence - Anti-Homeobox protein cut-like 1 antibody [CL5275] (AB242194)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Homeobox protein cut-like 1 antibody [CL5275] (AB242194)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Homeobox protein cut-like 1 antibody [CL5275] (AB242194)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (4)

Product promise