AB106251

Anti-HOPX/HOD antibody

Name: Anti-HOPX/HOD antibody
Brand: Abcam Limited
SKU: AB106251
Rating: 3 (5 reviews)

(5 리뷰들)

(3 제품이 사용된 논문 )

Rabbit Polyclonal HOPX/HOD antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HOPX.

대체 명칭 보기

HOD, HOP, LAGY, NECC1, OB1, HOPX, Homeodomain-only protein, Lung cancer-associated Y protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1

1 이미지

Unknown

Western blot - Anti-HOPX/HOD antibody (AB106251)

All lanes:

Western blot - Anti-HOPX/HOD antibody (ab106251) at 1/500 dilution

All lanes:

Human fetal heart tissue lysate

Predicted band size: 8 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human HOPX.

Q9BPY8

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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특성 및 보관 정보

제형

Lyophilized

Reconstitution

Reconstitute in 200 µL of water

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 1% BSA, 0.184% Tris glycine

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein HOPX also known as Homeodomain only protein is encoded by the HOPX gene. It is a small protein with a mass of approximately 8.5 kDa. HOPX is expressed in various tissues including cardiac myocytes epithelial tissues and stem cells. Known for its homeodomain-like structure HOPX does not bind DNA directly. Instead it influences transcription by interacting with other transcription factors and cofactors. The alternate name for HOPX is HOD and it serves as a reliable marker reflecting cellular differentiation and development.

Biological function summary

HOPX plays a role in regulating cell differentiation and tissue homeostasis. It acts without forming part of a larger protein complex primarily serving as a transcriptional regulator. This protein modulates the expression of genes critical for cell differentiation particularly in muscle and cardiac tissues. HOPX negatively regulates cell proliferation by modifying the transcription machinery influencing how cells enter mature states. Its role in differentiation makes it significant in both embryonic development and maintaining the integrity of adult cells.

Pathways

HOPX is significantly involved in the Wnt signaling pathway an important pathway in regulating cell fate across developmental stages. It modulates this pathway by interacting with proteins like β-catenin ensuring proper differentiation of various cell types. Another relevant pathway that includes HOPX is the BMP signaling pathway. Through this pathway HOPX contributes to osteogenesis and chondrogenesis working alongside proteins like SMADs which are effectors in the BMP pathway.

HOPX has implications in cancer and heart disease. Aberrant HOPX expression can lead to cancer progression particularly in lung and colon cancers. It seems to act as a tumor suppressor and its interactions with proteins like p53 highlight its role in cancer biology. Additionally HOPX's regulation in cardiac development links it to congenital heart defects when mutations or misregulation occur. Understanding HOPX's interactions in these contexts offers potential therapeutic insights.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed : 27708256).

See full target information HOPX

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

EMBO reports 25:4433-4464 PubMed39256596

2024

Terminal α1,2-fucosylation of glycosphingolipids by FUT1 is a key regulator in early cell-fate decisions.

Applications

Unspecified application

Species

Unspecified reactive species

Saray Chen,Dana Hayoun-Neeman,Michal Nagar,Sapir Pinyan,Limor Hadad,Liat Yaacobov,Lilach Alon,Liraz Efrat Shachar,Tair Swissa,Olga Kryukov,Orly Gershoni-Yahalom,Benyamin Rosental,Smadar Cohen,Rachel G Lichtenstein

Autophagy 20:1032-1053 PubMed37978868

2023

Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair.

Applications

Unspecified application

Species

Unspecified reactive species

Man J Livingston,Ming Zhang,Sang-Ho Kwon,Jian-Kang Chen,Honglin Li,Santhakumar Manicassamy,Zheng Dong

Frontiers in toxicology 4:840606 PubMed35832493

2022

A New Immortalized Human Alveolar Epithelial Cell Model to Study Lung Injury and Toxicity on a Breathing Lung-On-Chip System.

Applications

Unspecified application

Species

Unspecified reactive species

Arunima Sengupta,Nuria Roldan,Mirjam Kiener,Laurène Froment,Giulia Raggi,Theo Imler,Lea de Maddalena,Aude Rapet,Tobias May,Patrick Carius,Nicole Schneider-Daum,Claus-Michael Lehr,Marianna Kruithof-de Julio,Thomas Geiser,Thomas Michael Marti,Janick D Stucki,Nina Hobi,Olivier T Guenat

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-HOPX/HOD antibody

Western blot - Anti-HOPX/HOD antibody (AB106251)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Reconstitution

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise