JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB211521

Anti-HOXA7 antibody

Be the first to review this product! 리뷰 제출

|

(4 제품이 사용된 논문 )

Rabbit Polyclonal HOXA7 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Rat Hoxa7 aa 1-50 conjugated to Keyhole Limpet Haemocyanin.

대체 명칭 보기

HOX1A, HOXA7, Homeobox protein Hox-A7, Homeobox protein Hox 1.1, Homeobox protein Hox-1A

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXA7 antibody (AB211521)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXA7 antibody (AB211521)

Immunohistochemical analysis of Human skin tissue labeling HOXA7 with ab211521 at 5 μg/ml. Heat mediated antigen retrieval used.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Rat Hoxa7 aa 1-50 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P09634

style
left-column

대체품

Primary Antibodies

AB51235

Anti-HOXA7 antibody [743C1a]

Western blot - Anti-HOXA7 antibody [743C1a] (AB51235)

  • 0
  • 0

보완 제품

Primary Antibodies

AB140636

Anti-HOXA5 antibody [EPR2825(2)]

RabMAb|Recombinant

Western blot - Anti-HOXA5 antibody [EPR2825(2)] (AB140636)

  • 0
  • 0
Primary Antibodies

AB224731

Anti-SNAIL + SLUG antibody [CL3700] - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNAIL + SLUG antibody [CL3700] - N-terminal (AB224731)

  • 0
  • 0
Primary Antibodies

AB220390

Anti-HOXB2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-HOXB2 antibody (AB220390)

  • 0
  • 0
Primary Antibodies

AB52894

Anti-EGFR antibody [EP38Y]

BOND RX™ Validated|KO Validated|RabMAb|Lab Essentials|20ul selling size|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFR antibody [EP38Y] (AB52894)

  • 5
  • 24
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

HOXA7 also known as Homeobox A7 is a transcription factor in the HOX family involved in regulating gene expression. This protein plays a role in developmental processes by binding to specific DNA sequences. It has a molecular weight of around 25 kDa. The expression of HOXA7 occurs in various tissues but it is especially abundant in embryonic tissues indicating its role in early developmental stages. The protein’s activity is important for proper cell differentiation and positioning within developing organisms.
Biological function summary

HOXA7 participates in controlling the developmental blueprint of an organism. It acts as a transcriptional regulator within the family of homeobox genes which functions in concert to ensure organs and tissues develop in the correct order and positions. HOXA7 forms a part of the larger homeobox complex interacting with other HOX proteins to coordinate the precise expression of target genes. Disruptions in its activity can lead to misregulation of these essential developmental processes.

Pathways

The mechanistic activities of HOXA7 relate closely to the Wnt signaling pathway and the cell differentiation pathway. It cooperates with other HOX proteins such as HOXA9 and HOXB4 to modulate gene expression during development. The Wnt signaling pathway in particular plays an important role in cell proliferation and axis patterning. Its interaction with Wnt-related proteins helps achieve spatial and temporal regulation of developmental genes contributing to the finely tuned process of morphogenesis.

Aberrations in HOXA7 expression or function link to certain cancers and developmental disorders. In leukemia researchers observe abnormal expressions of HOXA7 suggesting it may contribute to the dysregulation of cell proliferation associated with this disease. Additionally the protein relates to skeletal malformations where its dysfunction results in improper bone development. In these contexts HOXA7 may interact with proteins such as MEIS1 which can modify its activity and impact cellular outcomes associated with these conditions.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
See full target information HOXA7
style
left-column

제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular biomedicine 5:32 PubMed39138733

2024

Effects of HOX family regulator-mediated modification patterns and immunity characteristics on tumor-associated cell type in endometrial cancer.

Applications

Unspecified application

Species

Unspecified reactive species

JiaoLin Yang,JinPeng Li,SuFen Li,YuTong Yang,HuanCheng Su,HongRui Guo,Jing Lei,YaLin Wang,KaiTing Wen,Xia Li,SanYuan Zhang,Zhe Wang

Cancer cell international 22:88 PubMed35183163

2022

HOXA7 promotes the metastasis of KRAS mutant colorectal cancer by regulating myeloid-derived suppressor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yunzhi Dang,Jiao Yu,Shuhong Zhao,Ximing Cao,Qing Wang

EBioMedicine 41:225-235 PubMed30737083

2019

A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes.

Applications

Unspecified application

Species

Unspecified reactive species

Irene Bertolini,Andrea Terrasi,Cristina Martelli,Gabriella Gaudioso,Andrea Di Cristofori,Alessandra Maria Storaci,Miriam Formica,Paola Braidotti,Katia Todoerti,Stefano Ferrero,Manuela Caroli,Luisa Ottobrini,Thomas Vaccari,Valentina Vaira

EBioMedicine 41:214-224 PubMed30737087

2019

Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea Terrasi,Irene Bertolini,Cristina Martelli,Gabriella Gaudioso,Andrea Di Cristofori,Alessandra Maria Storaci,Miriam Formica,Silvano Bosari,Manuela Caroli,Luisa Ottobrini,Thomas Vaccari,Valentina Vaira
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com