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AB243721

Anti-HOXC11 antibody

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(1 출판물)

Rabbit Polyclonal HOXC11 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HOXC11 aa 1-150.

대체 명칭 보기

HOX3H, HOXC11, Homeobox protein Hox-C11, Homeobox protein Hox-3H

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-HOXC11 antibody (AB243721)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-HOXC11 antibody (AB243721)

PFA-fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells labeling HOXC11 (Green) using ab243721 at 4 μg/mL in ICC/IF analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXC11 antibody (AB243721)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXC11 antibody (AB243721)

Formalin-fixed, paraffin-embedded human small intestine tissue stained for HOXC11 using ab243721 at 1/50 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human HOXC11 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

O43248

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보완 제품

Primary Antibodies

AB197246

Anti-DEPDC1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DEPDC1 antibody (AB197246)

  • 0
  • 0
Assay Kits

AB226900

Mouse Adiponectin ELISA Kit

SimpleStep

ELISA - Mouse Adiponectin ELISA Kit (AB226900)

  • 0
  • 0
Primary Antibodies

AB153904

Anti-HOXC10 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXC10 antibody (AB153904)

  • 5
  • 2
Primary Antibodies

AB188043

Anti-HOXC13 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXC13 antibody (AB188043)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

HOXC11 also known as Homeobox C11 is a protein that functions as a transcription factor. It belongs to the homeobox gene family and plays a role in regulating gene expression. HOXC11's molecular weight is approximately 34 kDa. This protein is mainly expressed in tissues like the breast prostate and placenta. Through DNA binding HOXC11 influences cellular processes by controlling the expression of various downstream target genes.
Biological function summary

HOXC11 acts as a regulator of embryonic development and differentiation. It forms part of the HOX gene complex that significantly contributes to the establishment of body plans and organogenesis. HOXC11 influences cellular proliferation and differentiation playing a critical role during morphogenetic events. The protein's expression patterns suggest its involvement in developing specific tissues leading to precise anatomical structures.

Pathways

The actions of HOXC11 integrate into important signaling cascades notably the Wnt signaling and retinoic acid pathways. Within the Wnt pathway HOXC11 interacts with other homeobox proteins to modulate gene expression and influence cell fate decisions. In the context of the retinoic acid pathway HOXC11 collaborates with proteins like HOXA9 to regulate the expression of genes involved in cellular differentiation and development. These pathways highlight HOXC11's function in finely tuning gene networks necessary for proper embryogenesis and tissue homeostasis.

Aberrant HOXC11 expression has associations with breast cancer and prostate cancer. In breast cancer abnormal regulation of HOXC11-linked genes may contribute to tumor progression. In prostate cancer HOXC11 interacts with AR (androgen receptor) influencing cancer cell growth and survival. Researchers focus on targeting the interaction of HOXC11 with other proteins to develop potential therapeutic approaches for treating these cancers.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.
See full target information HOXC11
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of bone oncology 28:100360 PubMed33996428

2021

Hsa_circ_0010220 regulates miR-198/Syntaxin 6 axis to promote osteosarcoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaoan Lu,Chuanwen Wang,Xiaolong Lv,Wen Dai
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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