AB50839

Anti-HOXC9 antibody [HOXCA6E6]

Name: Anti-HOXC9 antibody [HOXCA6E6]
Brand: Abcam Limited
SKU: AB50839
Rating: 5 (5 reviews)

(5 리뷰들)

(18 제품이 사용된 논문 )

Mouse Monoclonal HOXC9 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 18 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXC9.

2 이미지

Immunocytochemistry/ Immunofluorescence - Anti-HOXC9 antibody [HOXCA6E6] (AB50839)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-HOXC9 antibody [HOXCA6E6] (AB50839)

ab50839 at a 1/5 dilution staining HOXC9 in Hela cells using Alexa Fluor^® 488 Goat Anti-mouse IgG at a 1/200 dilution.

Unknown

Western blot - Anti-HOXC9 antibody [HOXCA6E6] (AB50839)

All lanes:

Western blot - Anti-HOXC9 antibody [HOXCA6E6] (ab50839) at 1/100 dilution

All lanes:

HT-1080 whole cell lysate at 50 µg

Secondary

All lanes:

Mouse IgG antibody at 1/2500 dilution

Predicted band size: 29 kDa

Observed band size: 29 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

HOXCA6E6

Isotype

IgG2b

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human HOXC9. The exact immunogen used to generate this antibody is proprietary information.

P31274

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/5", "ICCIF-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

purified from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (~95%) fetal bovine serum, filtered through a 0.22µm membrane.

보관 버퍼

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

HOXC9 also known as Homeobox C9 is a transcription factor that belongs to the homeobox family specifically the HOX gene cluster. It regulates gene expression by binding to specific DNA sequences. The protein has a molecular mass of about 28 kDa. HOXC9 is expressed in various tissues including the nervous system particularly during embryonic development. It plays an important role in patterning the anterior-posterior axis and the development of specific body structures.

Biological function summary

Genes that HOXC9 regulates play key roles in developmental processes such as neural differentiation and limb formation. HOXC9 might operate as part of a larger transcriptional complex that involves other HOX proteins allowing precise control over developmental gene expression. The protein ensures that cells at different developmental stages respond correctly to morphogenetic signals facilitating proper organismal formation.

Pathways

HOXC9 actively participates in the retinoic acid signaling pathway important for neurodevelopmental regulation. This pathway requires a balance between HOXC9 and Receptor Interacting Protein 1 (RIP1) for correct gene expression. Another critical pathway is the Wnt signaling pathway where HOXC9 interacts with components such as beta-catenin to further modulate gene transcription related to cell fate decisions.

Research links HOXC9 dysregulation to neurodevelopmental disorders and certain cancers like leukemia. Abnormal HOXC9 expression disrupts regular neural development and contributes to malignancy. Its interaction with proteins including members of the Polycomb group like Bmi1 influences these pathologies. Understanding HOXC9's involvement helps in devising therapeutic strategies for these conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

See full target information HOXC9

대체 명칭 보기

HOX3B, HOXC9, Homeobox protein Hox-C9, Homeobox protein Hox-3B

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제품이 사용된 논문 (18)

Recent publications for all applications. Explore the 전체 목록 and refine your search

iScience 28:112919 PubMed41054515

2025

Integrative multi-omics analysis decodes HOXC9-driven malignant transformation and metastasis in OSCC.

Applications

Unspecified application

Species

Unspecified reactive species

Mengyu Xu,Zewen Sun,Dandan Wang,Guoxin Li,Wei Feng,Chunyan Qiao,Ce Shi,Qilin Liu,Peng Chen,Zhengwen An

The EMBO journal 43:6310-6335 PubMed39528654

2024

METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ketan Thombare,Roshan Vaid,Perla Pucci,Kristina Ihrmark Lundberg,Ritish Ayyalusamy,Mohammad Hassan Baig,Akram Mendez,Rebeca Burgos-Panadero,Stefanie Höppner,Christoph Bartenhagen,Daniel Sjövall,Aqsa Ali Rehan,Sagar Dattatraya Nale,Anna Djos,Tommy Martinsson,Pekka Jaako,Jae-June Dong,Per Kogner,John Inge Johnsen,Matthias Fischer,Suzanne D Turner,Tanmoy Mondal

Cell stem cell 31:1113-1126.e6 PubMed38981471

2024

A human pluripotent stem cell-based somitogenesis model using microfluidics.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Liu,Yung Su Kim,Xufeng Xue,Yuchuan Miao,Norio Kobayashi,Shiyu Sun,Robin Zhexuan Yan,Qiong Yang,Olivier Pourquié,Jianping Fu

Cell reports methods 4:100777 PubMed38744289

2024

Effective cryopreservation of human brain tissue and neural organoids.

Applications

Unspecified application

Species

Unspecified reactive species

Weiwei Xue,Huijuan Li,Jinhong Xu,Xiao Yu,Linlin Liu,Huihui Liu,Rui Zhao,Zhicheng Shao

Nature communications 15:3745 PubMed38702304

2024

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations.

Applications

Unspecified application

Species

Unspecified reactive species

Ingrid M Saldana-Guerrero,Luis F Montano-Gutierrez,Katy Boswell,Christoph Hafemeister,Evon Poon,Lisa E Shaw,Dylan Stavish,Rebecca A Lea,Sara Wernig-Zorc,Eva Bozsaky,Irfete S Fetahu,Peter Zoescher,Ulrike Pötschger,Marie Bernkopf,Andrea Wenninger-Weinzierl,Caterina Sturtzel,Celine Souilhol,Sophia Tarelli,Mohamed R Shoeb,Polyxeni Bozatzi,Magdalena Rados,Maria Guarini,Michelle C Buri,Wolfgang Weninger,Eva M Putz,Miller Huang,Ruth Ladenstein,Peter W Andrews,Ivana Barbaric,George D Cresswell,Helen E Bryant,Martin Distel,Louis Chesler,Sabine Taschner-Mandl,Matthias Farlik,Anestis Tsakiridis,Florian Halbritter

Cell stem cell 30:264-282.e9 PubMed36868194

2023

hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Yujie Fan,James Hackland,Arianna Baggiolini,Lin Y Hung,Huiyong Zhao,Paul Zumbo,Polina Oberst,Andrew P Minotti,Emiliano Hergenreder,Sarah Najjar,Zixing Huang,Nelly M Cruz,Aaron Zhong,Mega Sidharta,Ting Zhou,Elisa de Stanchina,Doron Betel,Richard M White,Michael Gershon,Kara Gross Margolis,Lorenz Studer

iScience 26:105898 PubMed36647382

2023

Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing.

Applications

Unspecified application

Species

Unspecified reactive species

Weiwei Xue,Bo Li,Huihui Liu,Yujie Xiao,Bo Li,Lei Ren,Huijuan Li,Zhicheng Shao

eLife 11: PubMed36154671

2022

Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor.

Applications

Unspecified application

Species

Unspecified reactive species

Antigoni Gogolou,Celine Souilhol,Ilaria Granata,Filip J Wymeersch,Ichcha Manipur,Matthew Wind,Thomas J R Frith,Maria Guarini,Alessandro Bertero,Christoph Bock,Florian Halbritter,Minoru Takasato,Mario R Guarracino,Anestis Tsakiridis

Current protocols 1:e244 PubMed34547185

2021

In Vitro Generation of Posterior Motor Neurons from Human Pluripotent Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Matt Wind,Anestis Tsakiridis

Development (Cambridge, England) 148: PubMed33658223

2021

Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew Wind,Antigoni Gogolou,Ichcha Manipur,Ilaria Granata,Larissa Butler,Peter W Andrews,Ivana Barbaric,Ke Ning,Mario R Guarracino,Marysia Placzek,Anestis Tsakiridis

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-HOXC9 antibody [HOXCA6E6]

Immunocytochemistry/ Immunofluorescence - Anti-HOXC9 antibody [HOXCA6E6] (AB50839)

Western blot - Anti-HOXC9 antibody [HOXCA6E6] (AB50839)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reagents, Controls & Accessories

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (18)

Product promise