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AB235103

Anti-HOXD1 antibody

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Rabbit Polyclonal HOXD1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HOXD1 aa 50-150.

대체 명칭 보기

HOX4, HOX4G, HOXD1, Homeobox protein Hox-D1, Homeobox protein Hox-GG

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXD1 antibody (AB235103)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXD1 antibody (AB235103)

Paraffin-embedded human brain tissue stained for HOXD1 using ab235103 at 1/600 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at room temperature. Primary antibody (1% BSA) was incubated at 4°C overnight. The primary antibody was detected by a biotinylated secondary antibody and visualized using a HRP conjugated SP system.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human HOXD1 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q9GZZ0

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대체품

Primary Antibodies

AB220856

Anti-HOXD1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-HOXD1 antibody (AB220856)

  • 0
  • 0

보완 제품

Primary Antibodies

AB76093

Anti-HOXB4 antibody [EP1919Y]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-HOXB4 antibody [EP1919Y] (AB76093)

  • 0
  • 0
Primary Antibodies

AB229345

Anti-HOXB5 antibody

Immunoprecipitation - Anti-HOXB5 antibody (AB229345)

  • 0
  • 0
Primary Antibodies

AB2605

Anti-Menin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Menin antibody (AB2605)

  • 4
  • 1
Primary Antibodies

AB201682

Anti-HOXB13 antibody [EPR17371]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXB13 antibody [EPR17371] (AB201682)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

HOXD1 also known as Homeobox D1 is a transcription factor that plays a role in regulating gene expression. This protein has a mass of approximately 32 kDa. HOXD1 is part of the homeobox gene family which encodes transcription factors characterized by a specific sequence that binds DNA. HOXD1 shows expression in various tissues including the central nervous system and limbs during development. Its expression patterns suggest a role in the spatial and temporal regulation of developmental processes.
Biological function summary

HOXD1 contributes to the regulation of morphogenic development influencing the body layout along the anterior-posterior axis. It is not typically shown to be part of any larger protein complexes but interacts with other transcription factors to influence gene networks. During embryonic development HOXD1 orchestrates the activation and repression of target genes guiding proper morphogenesis and differentiation. This role is significant in setting positional identity and patterning of tissues.

Pathways

The HOXD1 protein participates in key developmental signaling pathways notably the Wnt signaling pathway. Wnt signaling affects cell proliferation polarity and migration making it critical during embryogenesis. HOXD1 collaborates with other homeobox genes like HOXA and HOXB clusters to ensure precise developmental patterning. The interactions among these homeobox proteins promote coordinated regulation of gene expression necessary for orderly development.

Alterations in HOXD1 expression have been linked to developmental disorders and certain cancers. Abnormal expression of HOXD1 may contribute to conditions such as synpolydactyly which affects limb development. Studies also suggest its potential involvement in various carcinomas due to its role in cell differentiation and proliferation. HOXD1's connections with other regulatory proteins like those in homeobox family suggest its mutation or dysregulation could influence similar associated disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
See full target information HOXD1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular biology of the cell 35:ar133 PubMed39196658

2024

mDia2 is an important mediator of MRTF-A-dependent regulation of breast cancer cell migration.

Applications

Unspecified application

Species

Unspecified reactive species

Ian Eder,Virginia Yu,Jacob Antonello,Fangyuan Chen,David Gau,Pooja Chawla,Marion Joy,Peter C Lucas,David Boone,Adrian V Lee,Partha Roy
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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