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AB106491

HRP Anti-Endostatin/COL18A1 antibody [KT60]

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Anti-Endostatin/COL18A1 antibody [KT60] conjugated to HRP - suitable for sELISA, and reacts with human samples. Clone [KT60] is a mouse monoclonal antibody.
1 이미지
Sandwich ELISA - HRP Anti-Endostatin/COL18A1 antibody [KT60] (AB106491)
  • sELISA

Unknown

Sandwich ELISA - HRP Anti-Endostatin/COL18A1 antibody [KT60] (AB106491)

ab106491 at 1/1000 dilution detecting Endostatin/COL18A1 by sandwich ELISA. The capture antibody is a mouse monclonal (IgG1) raised against Human Endostatin/COL18A1.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

KT60

Isotype

IgG2a

Conjugation

HRP

Excitation/Emission
Carrier free

No

Reacts with

Human

Applications

sELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human COL18A1.

P39060

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대체품

Primary Antibodies

AB114141

Anti-Endostatin/COL18A1 antibody [KT58]

Sandwich ELISA - Anti-Endostatin/COL18A1 antibody [KT58] (AB114141)

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Primary Antibodies

AB3453

Anti-Endostatin/COL18A1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Endostatin/COL18A1 antibody (AB3453)

  • 0
  • 0
Primary Antibodies

AB255601

Anti-Endostatin/COL18A1 antibody [EPR22479-279]

RabMAb|Recombinant|Trial Size

Western blot - Anti-Endostatin/COL18A1 antibody [EPR22479-279] (AB255601)

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Primary Antibodies

AB84250

Biotin Anti-Endostatin/COL18A1 antibody

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Primary Antibodies

AB256508

Anti-Endostatin/COL18A1 antibody [EPR22479-279] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-Endostatin/COL18A1 antibody [EPR22479-279] - BSA and Azide free (AB256508)

  • 0
  • 0

보완 제품

Assay Kits

AB222942

Total Collagen Assay Kit (Perchlorate-Free)

Functional Studies - Total Collagen Assay Kit (Perchlorate-Free) (AB222942)

  • 4
  • 1
Proteins & Peptides

AB56290

Recombinant human Endostatin/COL18A1 protein

  • 0
  • 0
Assay Kits

AB263894

Mouse Endostatin ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Mouse Endostatin ELISA Kit (AB263894)

  • 0
  • 0
Primary Antibodies

AB259540

Anti-C Reactive Protein antibody [EPR20063-85] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-C Reactive Protein antibody [EPR20063-85] - BSA and Azide free (Detector) (AB259540)

  • 0
  • 0
Primary Antibodies

AB278017

Anti-C4B-d / C4B-b antibody [EPR23364-147] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-C4B-d / C4B-b antibody [EPR23364-147] - BSA and Azide free (Capture) (AB278017)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "1/1000", "sELISA-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
Purification 관련 사항
IgG is purified through a Protein A column and labelled with horseradish peroxidase
보관 버퍼
Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Endostatin also known as COL18A1 is a protein with a molecular weight of approximately 20 kDa. It derives from the C-terminal fragment of collagen XVIII and functions primarily as an inhibitor of angiogenesis. Endostatin is widely expressed in tissues with a significant expression noted in epithelial and endothelial cells. Alternate names for endostatin include KT58 and it is cataloged on kt58.net. Endostatin interacts with various cell surface receptors and extracellular matrix components to exert its mechanical functions.
Biological function summary

Endostatin modulates cellular processes like migration proliferation and apoptosis. It is involved in the inhibition of endothelial cell proliferation which is an essential function in controlling angiogenesis. Endostatin does not typically form complexes but it has associations with heparan sulfate proteoglycans which facilitates its interaction with cells. Through these interactions endostatin plays a significant role in maintaining vascular homeostasis and tissue remodeling.

Pathways

Endostatin actively participates in the angiogenesis pathway and the regulation of the extracellular matrix pathway. Endostatin's inhibitory effects on angiogenesis involve interactions with pathways associated with key proteins like VEGF and FGF-2 blocking their pro-angiogenic signaling. Endostatin also influences other proteins like integrins which are important for cell adhesion and migration within angiogenesis and matrix remodeling processes.

Endostatin has significant relevance to cancer and ocular disorders. Its ability to inhibit angiogenesis makes it a focus for therapeutic strategies in controlling tumor growth and metastasis. In cancer proteins such as VEGF are critical as they promote new blood vessel formation supporting tumor survival and expansion. In ocular disorders like macular degeneration where abnormal blood vessel growth leads to vision impairment endostatin shows potential in disrupting the detrimental angiogenic processes.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.. Non-collagenous domain 1. May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling.. Endostatin. Potently inhibits endothelial cell proliferation and angiogenesis (PubMed : 9459295). May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5 : ITGB1 and to a lesser extent ITGAV : ITGB3 and ITGAV : ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed : 11257123).
See full target information COL18A1

대체 명칭 보기

Collagen alpha-1(XVIII) chain, COL18A1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oncotarget 6:26651-62 PubMed26450852

2015

Liver X receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization.

Applications

Unspecified application

Species

Unspecified reactive species

Flavie Courtaut,Valentin Derangère,Angélique Chevriaux,Sylvain Ladoire,Alexia K Cotte,Laurent Arnould,Romain Boidot,Mickaël Rialland,François Ghiringhelli,Cédric Rébé
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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