AB38905

HRP Anti-Plasmodium aldolase antibody

Name: HRP Anti-Plasmodium aldolase antibody
Brand: Abcam Limited
SKU: AB38905
Rating: 5 (1 reviews)

(1 리뷰)

(26 제품이 사용된 논문 )

Anti-Plasmodium aldolase antibody conjugated to HRP is a rabbit polyclonal antibody suitable for ELISA, Western blot, and reacts with Malaria Parasite P. Falciparum samples.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

HRP

Excitation/Emission

Carrier free

Reacts with

Plasmodium falciparum

Applications

ELISA, WB

applications

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Plasmodium falciparum": { "ELISA-species-checked": "testedAndGuaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 1.19% HEPES, 0.58% Sodium chloride, 0.2% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

+4°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Plasmodium aldolase also known as ALD or aldolase MW is an important enzyme in the glycolytic pathway. It has a molecular weight of approximately 39 kDa. The enzyme catalyzes the reversible cleavage of fructose-16-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. This reaction is important for energy production in the parasite Plasmodium which causes malaria. Plasmodium aldolase is expressed in various stages of the parasite's life cycle including the erythrocytic stage where the parasite infects red blood cells.

Biological function summary

Plasmodium aldolase plays a significant role in the survival and replication of the malaria parasite. It is not part of a larger protein complex but often associates with the cytoskeleton within the parasite facilitating its structural integrity and mobility. The enzyme's activity directly impacts the energy metabolism of Plasmodium making it essential for parasite survival and development in the host.

Pathways

Enzymes like Plasmodium aldolase operate within glycolytic and gluconeogenic pathways which are central to carbohydrate metabolism. In the glycolytic pathway aldolase sequentially interacts with proteins such as glyceraldehyde-3-phosphate dehydrogenase. Through its function in energy production aldolase indirectly supports various biosynthetic reactions and parasitic replication processes specific to Plasmodium.

Disturbances in Plasmodium aldolase function are directly linked to malaria one of the major global infectious diseases. The enzyme itself is a target for antimalarial drug development as inhibitors could potentially disrupt parasite energy metabolism leading to its death. Research also indicates a connection between aldolase and another protein lactate dehydrogenase which facilitates the parasite's anaerobic metabolism thereby contributing to its adaptability under different oxygen conditions in the human host.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information Plasmodium aldolase

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제품이 사용된 논문 (26)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Communications biology 8:142 PubMed39880906

2025

Pivotal roles of Plasmodium falciparum lysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalization.

Applications

Unspecified application

Species

Unspecified reactive species

Junpei Fukumoto,Minako Yoshida,Suzumi M Tokuoka,Eri Saki H Hayakawa,Shinya Miyazaki,Takaya Sakura,Daniel Ken Inaoka,Kiyoshi Kita,Jiro Usukura,Hideo Shindou,Fuyuki Tokumasu

Proceedings of the National Academy of Sciences of the United States of America 122:e2403689122 PubMed39773028

2025

Mutational analysis of an antimalarial drug target, ATP4.

Applications

Unspecified application

Species

Unspecified reactive species

Swaksha Rachuri,Binod Nepal,Anurag Shukla,Aarti Ramanathan,Joanne M Morrisey,Thomas Daly,Michael W Mather,Lawrence W Bergman,Sandhya Kortagere,Akhil B Vaidya

eLife 13: PubMed38921824

2024

RNA polymerase III is involved in regulating virulence.

Applications

Unspecified application

Species

Unspecified reactive species

Gretchen Diffendall,Aurelie Claes,Anna Barcons-Simon,Prince Nyarko,Florent Dingli,Miguel M Santos,Damarys Loew,Antoine Claessens,Artur Scherf

iScience 27:109760 PubMed38726364

2024

M--M mediated denaturation resistant P2 tetramer on the infected erythrocyte surface of malaria parasite imports serum fatty acids.

Applications

Unspecified application

Species

Unspecified reactive species

Sudipta Das,Anwesa Manna,Oindrila Majumdar,Lena Dhara

Pharmaceutics 15: PubMed37896200

2023

Epidrugs as Promising Tools to Eliminate Artemisinin-Resistant and Quiescent Parasites.

Applications

Unspecified application

Species

Unspecified reactive species

Thibaud Reyser,Lucie Paloque,Michel Nguyen,Jean-Michel Augereau,Matthew John Fuchter,Marie Lopez,Paola B Arimondo,Storm Hassell-Hart,John Spencer,Luisa Di Stefano,Françoise Benoit-Vical

ACS infectious diseases 9:1257-1266 PubMed37216290

2023

Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors.

Applications

Unspecified application

Species

Unspecified reactive species

Irina Dobrescu,Elie Hammam,Jerzy M Dziekan,Aurélie Claës,Ludovic Halby,Peter Preiser,Zbynek Bozdech,Paola B Arimondo,Artur Scherf,Flore Nardella

Nature 612:528-533 PubMed36477538

2022

A transcriptional switch controls sex determination in Plasmodium falciparum.

Applications

Unspecified application

Species

Unspecified reactive species

A R Gomes,A Marin-Menendez,S H Adjalley,C Bardy,C Cassan,M C S Lee,A M Talman

Life science alliance 6: PubMed36379669

2022

Discovery of RUF6 ncRNA-interacting proteins involved in immune evasion.

Applications

Unspecified application

Species

Unspecified reactive species

Gretchen M Diffendall,Anna Barcons-Simon,Sebastian Baumgarten,Florent Dingli,Damarys Loew,Artur Scherf

PLoS pathogens 18:e1010887 PubMed36223427

2022

Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites.

Applications

Unspecified application

Species

Unspecified reactive species

Timothy James Russell,Erandi K De Silva,Valerie M Crowley,Kathryn Shaw-Saliba,Namita Dube,Gabrielle Josling,Charisse Flerida A Pasaje,Irene Kouskoumvekaki,Gianni Panagiotou,Jacquin C Niles,Marcelo Jacobs-Lorena,C Denise Okafor,Francisco-Javier Gamo,Manuel Llinás

Journal of medicinal chemistry 64:10403-10417 PubMed34185525

2021

Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.

Applications

Unspecified application

Species

Unspecified reactive species

Flore Nardella,Ludovic Halby,Irina Dobrescu,Johanna Viluma,Corentin Bon,Aurélie Claes,Véronique Cadet-Daniel,Ambre Tafit,Camille Roesch,Elie Hammam,Diane Erdmann,Melissa Mairet-Khedim,Roger Peronet,Salah Mecheri,Benoit Witkowski,Artur Scherf,Paola B Arimondo

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

HRP Anti-Plasmodium aldolase antibody

주요 정보

Host species

Clonality

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (26)

Product promise