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AB21112

Anti-HSV2 antibody

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(4 제품이 사용된 논문 )

Sheep Polyclonal HSV2 antibody. Suitable for ELISA, WB, Conjugation, ICC/IF, IM and reacts with Human herpesvirus 2 samples. Cited in 4 publications. Immunogen corresponding to Virus preparation containing HSV2 protein.

대체 명칭 보기

Herpes Simplex Virus Type 2

주요 정보

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human herpesvirus 2

Applications

ELISA, ICC/IF, WB, Conjugation, IM

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Primary Antibodies

AB9533

Anti-HSV1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSV1 antibody (AB9533)

  • 5
  • 2
Primary Antibodies

AB18687

Anti-HSV2 gB antibody [1-G-10]

  • 0
  • 0
Primary Antibodies

AB6513

Anti-HSV1 ICP0 antibody [5H7]

Immunocytochemistry/ Immunofluorescence - Anti-HSV1 ICP0 antibody [5H7] (AB6513)

  • 5
  • 1
Primary Antibodies

AB6506

Anti-HSV1 + HSV2 gB antibody [10B7]

Immunocytochemistry/ Immunofluorescence - Anti-HSV1 + HSV2 gB antibody [10B7] (AB6506)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "Conjugation" : {"fullname" : "Conjugation", "shortname":"Conjugation"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IM" : {"fullname" : "Immunomicroscopy", "shortname":"IM"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human herpesvirus 2": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "Conjugation-species-checked": "guaranteed", "Conjugation-species-dilution-info": "", "Conjugation-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IM-species-checked": "guaranteed", "IM-species-dilution-info": "", "IM-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Ion exchange chromatography
Purification 관련 사항
>95% pure. Sodium sulphate precipitation and ion exchange chromatography.
보관 버퍼
Preservative: 0.1% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Herpes Simplex Virus type 2 (HSV2) also known as Human Herpesvirus 2 is a member of the herpesviridae family. It mainly affects the genital region and is a common cause of genital herpes. The virus has a double-stranded DNA genome with a mass of approximately 152 kbp. HSV2 primarily expresses in epithelial cells of the skin and mucous membranes. It can establish latency in neuronal cells especially the sacral ganglia contributing to its ability to persist in the host for life.
Biological function summary

HSV2 exhibits a complex life cycle involving both lytic and latent phases. During infection the virus interacts with cellular compartments including the nucleus where it hijacks host cell machinery to replicate its genome. In the latent phase HSV2 becomes dormant in sensory neurons avoiding host immune detection. It is not part of a larger complex but relies on numerous viral proteins for successful replication and invasion such as glycoproteins critical for host entry.

Pathways

HSV2 interacts with multiple immune evasion and inflammatory pathways. It manipulates the NF-kB signaling pathway an important player in inflammation and immune responses. The virus evades immune detection by inhibiting the activation of NF-kB allowing persistent infection. HSV2 also affects the MAPK signaling pathway through viral proteins such as ICP34.5 which modulate host defense mechanisms and facilitate viral replication.

HSV2 is significantly associated with genital herpes and is linked to an increased risk of HIV acquisition. Genital herpes can cause recurrent painful lesions and can be transmitted to neonates during childbirth leading to neonatal herpes. The virus's interaction with host immune pathways might also modify the host's susceptibility to other sexually transmitted infections including HIV. HSV2 through its impact on the host's immune response shares interactions with proteins like HIV-1 gp120 in co-infected individuals which complicates the management of these infections.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information HSV2
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in immunology 13:983502 PubMed36211339

2022

Herpes simplex virus type 2 inhibits TNF-α-induced NF-κB activation through viral protein ICP22-mediated interaction with p65.

Applications

Unspecified application

Species

Unspecified reactive species

Huimin Hu,Ming Fu,Chuntian Li,Binman Zhang,Yuncheng Li,Qinxue Hu,Mudan Zhang

Human gene therapy 33:649-663 PubMed35272497

2022

Bispecific Antibody Expressed by an Oncolytic Herpes Simplex Virus Type 2 Can Transform Heterologous T Cells Into Uniform Tumor Killer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Jin,Runyang Wang,Junhan Yang,Han Hu,Di Wang,Linkang Cai,Zhizheng Fang,Shuang Dong,Sheng Hu,Yang Wang,Binlei Liu

Frontiers in microbiology 10:2790 PubMed31849920

2019

Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2.

Applications

Unspecified application

Species

Unspecified reactive species

Martin Michaelis,Malte C Kleinschmidt,Denisa Bojkova,Holger F Rabenau,Mark N Wass,Jindrich Cinatl

Frontiers in immunology 9:2932 PubMed30619292

2018

Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4 T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4.

Applications

Unspecified application

Species

Unspecified reactive species

Mudan Zhang,Xu Deng,Xinmeng Guan,Lanlan Geng,Ming Fu,Binman Zhang,Rui Chen,Huimin Hu,Kai Hu,Di Zhang,Mei Li,Yalan Liu,Sitang Gong,Qinxue Hu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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