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AB235520

Anti-IFRD2 antibody

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(1 출판물)

Rabbit Polyclonal IFRD2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IFRD2 aa 1-250.

대체 명칭 보기

Interferon-related developmental regulator 2, Protein SKMC15, IFRD2

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFRD2 antibody (AB235520)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFRD2 antibody (AB235520)

Paraffin-embedded human placenta tissue stained for IFRD2 using ab235520 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human IFRD2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q12894

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보완 제품

Primary Antibodies

AB154270

Anti-OAS3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OAS3 antibody (AB154270)

  • 0
  • 0
Primary Antibodies

AB203517

Anti-BTF3 antibody [EPR16495]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-BTF3 antibody [EPR16495] (AB203517)

  • 5
  • 1
Primary Antibodies

AB224619

Anti-NOB1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NOB1 antibody (AB224619)

  • 0
  • 0
Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

IFRD2 also known as Interferon-Related Developmental Regulator 2 is a protein with a mass of approximately 35 kDa. This protein belongs to the IFRD family and is expressed in various tissues with higher levels observed in the brain and muscle tissues. It participates in transcription regulation and signal transduction. IFRD2's expression is modulated in response to different cytokines and growth factors indicating its involvement in cell signaling and development.
Biological function summary

IFRD2 influences cell differentiation and development by regulating gene expression. It forms part of a larger complex interacting with other proteins involved in transcriptional modulation. This protein plays a role in cellular responses to environmental changes and cellular growth. Its presence contributes to the fine-tuning of transcriptional machinery essential for proper cellular function.

Pathways

IFRD2 is involved in the cellular response to stress and developmental pathways. It participates in the interactions between nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and histone deacetylases (HDACs) important for inflammatory response regulation. IFRD2 affects these pathways by modulating the activity and interactions of proteins within these signaling networks.

IFRD2 exhibits connections to neurodegenerative diseases and muscle disorders. Alterations in IFRD2 expression have shown links to conditions such as Alzheimer's disease where it interacts with tau proteins affecting neurofibrillary tangle formation. In muscle disorders variations in IFRD2 levels correlate with muscle atrophy in association with proteins like myostatin influencing muscle mass and function. Its role in these conditions highlights its potential target for therapeutic intervention.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Ribosome-binding protein that acts as an inhibitor of mRNA translation by promoting ribosome inactivation (PubMed : 30355441). Associates with the P- and E-sites of the ribosome and inserts a C-terminal helix into the mRNA exit channel to preclude translation (By similarity).
See full target information IFRD2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer medicine 12:5035-5054 PubMed36205357

2022

Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance.

Applications

Unspecified application

Species

Unspecified reactive species

Min Tang,Juan Chen,Tian Zeng,Dong-Mei Ye,Yu-Kun Li,Juan Zou,Yu-Ping Zhang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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