AB239526

Anti-IL36 gamma/IL-1F9 antibody [D2]

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Mouse Monoclonal IL36 gamma/IL-1F9 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Il36g aa 1-150.

대체 명칭 보기

Il1f9, Il36g, Interleukin-36 gamma, Interleukin-1 family member 9, IL-1F9

7 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

Paraffin-embedded mouse intestine tissue stained for IL36 gamma/IL-1F9 using ab239526 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

Paraffin-embedded mouse colon tissue stained for IL36 gamma/IL-1F9 using ab239526 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

Paraffin-embedded mouse lung tissue stained for IL36 gamma/IL-1F9 using ab239526 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

Paraffin-embedded mouse kidney tissue stained for IL36 gamma/IL-1F9 using ab239526 at 30 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

Paraffin-embedded mouse liver tissue stained for IL36 gamma/IL-1F9 using ab239526 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

All lanes:

Western blot - Anti-IL36 gamma/IL-1F9 antibody [D2] (ab239526) at 5 µg/mL

All lanes:

Recombinant mouse IL36 gamma/IL-1F9 protein

Predicted band size: 19 kDa

false

Supplier Data

Western blot - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

All lanes:

Western blot - Anti-IL36 gamma/IL-1F9 antibody [D2] (ab239526) at 3 µg/mL

All lanes:

Rat serum

Predicted band size: 19 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

Isotype

IgG2a

Light chain 타입

kappa

Carrier free

Reacts with

Rat, Mouse

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Mouse Il36g aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q8R460

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-30 µg/mL", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A/G

Purification 관련 사항

Purified from TCS.

보관 버퍼

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

IL36 gamma also known as IL-1F9 or IL-36 is a member of the interleukin-1 cytokine family. The protein weighs approximately 22 kDa. It is expressed highly in epithelial tissues such as keratinocytes in the skin bronchial tissues and intestinal lining. It acts mainly on nearby cells to influence immune responses through cytokine signaling.

Biological function summary

IL36 gamma plays a role in the immune and inflammatory responses. It operates as a cytokine that signals through the IL-1 receptor family leading to the activation of NF-kB and MAPK pathways. This member of the IL-1 family does not form a complex by itself but interacts with IL-36R to exert its functions. The protein influences processes such as cell proliferation differentiation and the regulation of immune responses to external pathogens or injuries.

Pathways

IL36 gamma is involved in inflammatory and immune signaling pathways. Within the immune response pathway it stimulates the production of other cytokines and pro-inflammatory molecules. IL36 gamma is associated with the IL-1 signaling pathway alongside other cytokines such as IL-1 and IL-18 which all contribute to immune modulation and inflammatory responses.

IL36 gamma has connections to psoriasis and inflammatory bowel disease. In psoriasis increased levels of IL36 gamma correlate with heightened skin inflammation and proliferation of keratinocytes. In inflammatory bowel disease IL36 gamma contributes to the inflammatory state of the gut. The activities of IL36 gamma often link with other cytokines such as TNF-alpha which collectively drive the inflammatory processes observed in these conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Functions as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation. May be involved in the innate immune response to fungal pathogens. Induces the production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes.

See full target information Il36g

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 15:33150 PubMed41006496

2025

Neonatal sevoflurane exposure enhances stress-related neurological susceptibility via NKCC1 modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Bi-Ying Yuan,Li-Hui Shan,Jiang Zou,Xiao-Hai Xie,Jia-Qi Gan,Ben-Zhen Chen

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IL36 gamma/IL-1F9 antibody [D2]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

Western blot - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

Western blot - Anti-IL36 gamma/IL-1F9 antibody [D2] (AB239526)

주요 정보

Host species

Clonality

Clone number

Isotype

Light chain 타입

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Assay Kits

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise