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AB235323

Anti-IMPACT antibody

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Rabbit Polyclonal IMPACT antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IMPACT aa 1-350.

대체 명칭 보기

Protein IMPACT, Imprinted and ancient gene protein homolog, IMPACT

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPACT antibody (AB235323)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPACT antibody (AB235323)

Paraffin-embedded human endometrial cancer tissue stained for IMPACT using ab235323 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPACT antibody (AB235323)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPACT antibody (AB235323)

Paraffin-embedded human kidney tissue stained for IMPACT using ab235323 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human IMPACT aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

Q9P2X3

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대체품

Primary Antibodies

AB72444

Anti-IMPACT antibody

Western blot - Anti-IMPACT antibody (AB72444)

  • 0
  • 0
Primary Antibodies

AB95175

Anti-IMPACT antibody

Immunoprecipitation - Anti-IMPACT antibody (AB95175)

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보완 제품

Proteins & Peptides

AB201366

Recombinant Flagellin protein

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

IMPACT also known as Impact homolog or CI-68 is a protein that has around 33 kDa molecular weight. It is well-conserved across species and has significant expression in the brain. The protein can bind to ribosomes potentially influencing translation regulation. IMPACT can modulate translation initiation and is detected in other tissues but with lesser intensity than in the brain.
Biological function summary

The regulation of translation initiation is a critical function that IMPACT performs. It is thought to affect the cellular stress response by interacting with components of the translation machinery. IMPACT does not function as part of a large complex but influences the availability of translation factors. This influence is essential in neurons where it helps them survive under various environmental stress conditions.

Pathways

IMPACT plays a role in the mTOR signaling and integrated stress response pathways. Through these it influences protein synthesis and cellular stress management. IMPACT is related to proteins like GCN2 which allows cells to adapt to amino acid availability and eIF2α which is important for the translation initiation regulations in response to stress signals.

Alterations in IMPACT expression have links to neurodegenerative diseases and mental health disorders. In Alzheimer's Disease for example its regulation of protein synthesis is considered important in disease progress interacting with other proteins like tau. Additionally through stress response modulation IMPACT is associated with mood disorders due to its role in synaptic plasticity and neuron survival under stress conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
See full target information IMPACT
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oncology letters 21:185 PubMed33574924

2021

A comprehensive analysis of the expression, epigenetic and genetic changes of HNF1B and ECI2 in 122 cases of high-grade serous ovarian carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Kristýna Němejcová,Michaela Bártů,Jan Hojný,Nikola Hájková,Romana Michálková,Eva Krkavcová,Ivana Stružinská,Hiep Quang Bui,Pavel Dundr,David Cibula,Kateřina Jirsová
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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