AB236391

Anti-INPP5F antibody [OTI1D4]

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(2 제품이 사용된 논문 )

Mouse Monoclonal INPP5F antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human INPP5F.

대체 명칭 보기

KIAA0966, SAC2, MSTP007, MSTP047, INPP5F, Phosphatidylinositide 4-phosphatase SAC2, Inositol polyphosphate 5-phosphatase F, Sac domain-containing inositol phosphatase 2, Sac domain-containing phosphoinositide 4-phosphatase 2, hSAC2

1 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INPP5F antibody [OTI1D4] (AB236391)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INPP5F antibody [OTI1D4] (AB236391)

Paraffin-embedded human pancreas tissue stained for INPP5F using ab236391 at 1/500 dilution in immunohistochemical analysis.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI1D4

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human INPP5F.

Q9Y2H2

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p>Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 8.5 before commencing with IHC staining protocol.</p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification

Purification 관련 사항

Purified from cell culture supernatant.

보관 버퍼

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

INPP5F also known as phosphatidylinositol-45-bisphosphate 5-phosphatase F functions as a lipid phosphatase that removes 5-phosphate groups from phosphoinositides. These molecules are important for cellular signaling pathways. INPP5F has a molecular mass of approximately 75 kDa. It is expressed in various tissues with higher levels found in the brain and heart. This suggests its importance in specific cellular tissues for specialized roles.

Biological function summary

Removing phosphate groups from phosphoinositides impacts cell signaling and membrane dynamics. INPP5F modulates cellular processes including cytoskeletal organization and vesicle trafficking through its phosphatase activity. It does not appear to be part of any stable complexes but regulates its substrates and influences processes through its enzymatic action.

Pathways

INPP5F participates in important signaling pathways such as the phosphatidylinositol signaling system and the PI3K-Akt pathway. These pathways are essential for controlling cell growth and survival. INPP5F is functionally related to other phosphatases including PTEN which also act within these pathways to balance signaling activities for normal cellular function.

INPP5F has been linked to cardiovascular diseases and certain neurodegenerative disorders. Disturbances in its activity can result in altered signaling impacting heart function and brain health. It connects to proteins like Akt through the PI3K pathway in cardiovascular contexts whereas disruptions may influence Alzheimer's disease pathology by affecting cellular signaling and regulation.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed : 25869669). Regulator of TF : TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed : 25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed : 17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed : 25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).

See full target information INPP5F

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Redox biology 73:103207 PubMed38805974

2024

Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Shuohui Dong,Mingguang Zhang,Zhiqiang Cheng,Xiang Zhang,Weili Liang,Songhan Li,Linchuan Li,Qian Xu,Siyi Song,Zitian Liu,Guangwei Yang,Xiang Zhao,Ze Tao,Shuo Liang,Kexin Wang,Guangyong Zhang,Sanyuan Hu

Journal of experimental & clinical cancer research : CR 41:13 PubMed34996491

2022

INPP5F translocates into cytoplasm and interacts with ASPH to promote tumor growth in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qianlei Zhou,Jianhong Lin,Yongcong Yan,Shiyu Meng,Hao Liao,Ruibin Chen,Gui He,Yue Zhu,Chuanchao He,Kai Mao,Jie Wang,Jianlong Zhang,Zhenyu Zhou,Zhiyu Xiao

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-INPP5F antibody [OTI1D4]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INPP5F antibody [OTI1D4] (AB236391)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise