AB243023

Anti-Integrin beta 8 antibody [CL7290]

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(3 제품이 사용된 논문 )

Mouse Monoclonal Integrin beta 8 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Integrin beta-8 aa 550 to C-terminus.

대체 명칭 보기

Integrin beta-8, ITGB8

2 이미지

Immunocytochemistry/ Immunofluorescence - Anti-Integrin beta 8 antibody [CL7290] (AB243023)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Integrin beta 8 antibody [CL7290] (AB243023)

Immunocytochemistry/Immunofluorescence analysis of WM-115 cells labeling Integrin beta 8 using ab243023 at 4 μg/ml (green). Nuclear probe is visualized in blue, microtubules in red.

Supplier Data

Western blot - Anti-Integrin beta 8 antibody [CL7290] (AB243023)

All lanes:

Western blot - Anti-Integrin beta 8 antibody [CL7290] (ab243023) at 1 µg/mL

All lanes:

Human eye tissue lysate

Predicted band size: 86 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

CL7290

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human Integrin beta-8 aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P26012

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "2-10 mg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

Purification 관련 사항

Purified from TCS.

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Integrin beta 8 also known as β8 integrin or ITGB8 is a transmembrane protein that functions mechanically as part of the integrin family. It forms heterodimers with the alpha v subunit resulting in the integrin alpha v beta 8 complex. This complex plays a role in cell adhesion and signaling by binding to extracellular matrix proteins like latency-associated peptide TGF-β. Integrin beta 8 is expressed in various tissues notably in the brain lungs and intestinal epithelium. The protein has a mass of approximately 85 kDa.

Biological function summary

Integrin beta 8 participates in the regulation of cellular processes such as growth differentiation and migration. The integrin alpha v beta 8 complex serves as a receptor for latent TGF-β activation an important step in modulating TGF-β signaling. This activation influences processes such as extracellular matrix remodeling and immune response regulation. Integrin beta 8 interacts with actin cytoskeleton regulatory proteins to mediate these cellular changes.

Pathways

Integrin beta 8 influences both TGF-β and Wnt signaling pathways. Its role in TGF-β pathway involves activation of latent TGF-β impacting tissue homeostasis and immune regulation. In connection to Wnt signaling integrin beta 8 modulates cell proliferation and differentiation. The protein shares functional relations with other integrins like integrin beta 6 which also interacts with similar ligands and pathways coordinating cellular response during development and repair processes.

Integrin beta 8 associates with conditions like brain tumors and fibrosis. For example its upregulation in glioblastoma multiforme contributes to the invasive properties of tumor cells by modulating TGF-β signaling similar to the role observed with integrin beta 6 in fibrotic diseases. This connection emphasizes the therapeutic potential of targeting integrin beta 8 to mitigate disease progression and improve treatment efficacy.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Integrin alpha-V : beta-8 (ITGAV : ITGB8) is a receptor for fibronectin (PubMed : 1918072). It recognizes the sequence R-G-D in its ligands (PubMed : 1918072). Integrin alpha-V : beta-6 (ITGAV : ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity).

See full target information Integrin beta-8

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer cell international 25:135 PubMed40200265

2025

Single-cell transcriptome sequencing reveals the mechanism of Realgar improvement on erythropoiesis in mice with myelodysplastic syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Xu,Kexin Hu,Yanlu Wang,Shuyang Cai,Fan Wu,Jizhang Bao,Qi Hu,Yu Guan,Yuchen Tao,Jiahui Lu

Molecular medicine (Cambridge, Mass.) 30:277 PubMed39725889

2024

Investigating the inflammatory mechanism of notoginsenoside R1 in Diabetic nephropathy via ITGB8 based on network pharmacology and experimental validation.

Applications

Unspecified application

Species

Unspecified reactive species

ChangYan Li,Chen Geng,JiangMing Wang,Luyao Shi,JingYuan Ma,Zhang Liang,WenXing Fan

Cell death discovery 8:454 PubMed36371410

2022

LINC00472 inhibits cell migration by enhancing intercellular adhesion and regulates H3K27ac level via interacting with P300 in renal clear cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Songmao Wang,Cheng Luo,Bing Li,Shikuan Zhang,Weijie Liao,Qilei Xin,Naihan Xu,Weidong Xie,Yuanchang Zhu,Yaou Zhang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Integrin beta 8 antibody [CL7290]

Immunocytochemistry/ Immunofluorescence - Anti-Integrin beta 8 antibody [CL7290] (AB243023)

Western blot - Anti-Integrin beta 8 antibody [CL7290] (AB243023)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise