JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB236772

Anti-IPP antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal IPP antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IPP aa 400-550.

대체 명칭 보기

KLHL27, IPP, Actin-binding protein IPP, Intracisternal A particle-promoted polypeptide, Kelch-like protein 27

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-IPP antibody (AB236772)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-IPP antibody (AB236772)

HepG2 (Human liver hepatocellular carcinoma cell line) cells stained for IPP using ab236772 at a dilution of 1/100 in ICC/IF. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IPP antibody (AB236772)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IPP antibody (AB236772)

Paraffin-embedded human kidney tissue stained for IPP with ab236772 at a 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human IPP aa 400-550. The exact immunogen used to generate this antibody is proprietary information.

Q9Y573

style
left-column

보완 제품

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB237811

Anti-ZNF695 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF695 antibody (AB237811)

  • 0
  • 0
Primary Antibodies

AB237623

Anti-WDFY2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-WDFY2 antibody (AB237623)

  • 0
  • 0
Primary Antibodies

AB236887

Anti-TPPP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPPP2 antibody (AB236887)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The molecule isopentenyl pyrophosphate (IPP) sometimes referred to as isopentenyl diphosphate serves as an important intermediate in the biosynthesis of terpenes and isoprenoids. IPP a small molecule with a molecular mass of 246.1 g/mol participates in various enzymatic reactions within the mevalonate pathway. This pathway occurs in the cytosol of eukaryotic cells and the peroxisomes in plants. In terms of its expression while IPP is not a protein or gene with specific expression levels the enzymes related to its synthesis and utilization show varying activity across different tissues.
Biological function summary

IPP functions as a precursor for various essential isoprenoid compounds encompassing sterols dolichols and ubiquinones. It acts within a network of enzymes converting basic building blocks into complex molecules that maintain cell membranes and facilitate electron transport. These reactions often involve enzyme complexes like synthases that regulate the flow of intermediates. Moreover IPP plays a substantial role in the synthesis of other molecules like cholesterol and steroid hormones reflecting its broad biological influence.

Pathways

IPP engages prominently in the mevalonate and the methylerythritol phosphate (MEP) pathways. The mevalonate pathway produces isoprenoids which are vital for cell growth and development. Within these pathways IPP can interconvert with dimethylallyl pyrophosphate (DMAPP) another critical molecule. Enzymes like HMG-CoA reductase and isopentenyl-diphosphate isomerase control these reactions linking IPP to key biological pathways involved in metabolic regulation and cellular differentiation.

IPP's significance links to disorders related to cholesterol metabolism and immune system dysregulation. Defects in the mevalonate pathway associate with diseases like mevalonate kinase deficiency influencing levels of inflammatory proteins. Moreover IPP accumulation can activate immune cells through the recognition by Vγ9/VΔ2 T-cells implicating it in conditions such as autoimmunity or inflammation. This connection highlights the consequence of IPP in understanding metabolic and immune-related disorders.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

May play a role in organizing the actin cytoskeleton.
See full target information IPP
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Environmental toxicology 39:991-1000 PubMed37994395

2023

ASIC1a contributes to the epithelial-mesenchymal transformation of breast cancer by activating the Ca /β-catenin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jiawei Wang,Chao Yang,Ruihua Yu,Ming Zhuang,Feng Jiang
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com