JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB235776

Anti-ISCA2 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal ISCA2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ISCA2.

대체 명칭 보기

HBLD1, ISCA2, HESB-like domain-containing protein 1

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISCA2 antibody (AB235776)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISCA2 antibody (AB235776)

Paraffin-embedded human tonsil tissue stained for ISCA2 using ab235776 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISCA2 antibody (AB235776)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISCA2 antibody (AB235776)

Paraffin-embedded human prostate cancer tissue stained for ISCA2 using ab235776 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ISCA2.

Q86U28

style
left-column

보완 제품

Primary Antibodies

AB180161

Anti-C1orf69/IBA57 antibody [EPR11758(2)]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-C1orf69/IBA57 antibody [EPR11758(2)] (AB180161)

  • 0
  • 0
Primary Antibodies

AB204310

Anti-Ferredoxin Reductase antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ferredoxin Reductase antibody (AB204310)

  • 0
  • 0
Primary Antibodies

AB14746

Anti-UQCRFS1/RISP antibody [5A5]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRFS1/RISP antibody [5A5] (AB14746)

  • 4
  • 5
Primary Antibodies

AB14744

Anti-COX IV antibody [20E8C12] - Mitochondrial Marker

Lab Essentials

Western blot - Anti-COX IV antibody [20E8C12] - Mitochondrial Marker (AB14744)

  • 5
  • 23
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ISCA2 also known as Iron-Sulfur Cluster Assembly 2 is a protein involved in the assembly of iron-sulfur clusters essential for various cellular processes. This protein has a molecular weight of approximately 14 kDa. ISCA2 is expressed in numerous tissues including the heart liver and skeletal muscles. It plays a fundamental role in the synthesis of these clusters which are integral for electron transfer and enzymatic reactions.
Biological function summary

The protein ISCA2 participates in the maturation of iron-sulfur cluster-containing proteins critical for mitochondrial function. As part of a larger complex ISCA2 collaborates with other proteins like ISCA1 and IBA57 to facilitate the transfer and insertion of these clusters into target proteins. This action supports the stability and functionality of key mitochondrial enzymes assisting in cellular respiration and redox homeostasis.

Pathways

Iron-sulfur cluster biogenesis involves ISCA2 and integrates into critical pathways like the mitochondrial respiratory chain and the citric acid cycle. Within these pathways ISCA2 operates alongside related proteins such as NFS1 and FXN ensuring proper cluster delivery and activity. These pathways are vital for maintaining cellular energy production and metabolic balance emphasizing ISCA2's significant role.

ISCA2 mutations have been implicated in mitochondrial diseases like multiple mitochondrial dysfunctions syndrome (MMDS). This disorder includes neurologic abnormalities due to defective mitochondrial protein function. ISCA2 is connected to MMDS alongside proteins such as ISCA1 and IBA57 which also partake in the cluster assembly machinery highlighting the protein's broader importance in human health.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.
See full target information ISCA2
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell death & disease 16:405 PubMed40393967

2025

Cellular crosstalk mediated by Meteorin-like regulating hepatic stellate cell activation during hepatic fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxia Zhou,Guifang Wang,Lingling Liu,Lingyu Song,Laying Hu,Lu Liu,Lifen Xu,Tuanlao Wang,Lirong Liu,Yuanyuan Wang,Tian Zhang,Bing Guo
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com