AB75224

Anti-ITGA7 antibody

Name: Anti-ITGA7 antibody
Brand: Abcam Limited
SKU: AB75224
Rating: 4 (3 reviews)

(3 리뷰들)

(6 제품이 사용된 논문 )

Rabbit Polyclonal ITGA7 antibody. Suitable for ELISA, WB, IHC-Fr, IHC-P and reacts with Human, African green monkey samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human ITGA7.

1 이미지

Unknown

Western blot - Anti-ITGA7 antibody (AB75224)

All lanes:

Western blot - Anti-ITGA7 antibody (ab75224) at 1/500 dilution

Lane 1:

COS-7 cells, treated with etoposide (25 µM, 1 hour) at 5 µg

Lane 2:

COS-7 cells, treated with etoposide (25 µM, 1 hour) at 5 µg with Cl-peptide

Predicted band size: 129 kDa

Observed band size: 26 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

African green monkey, Human

Applications

IHC-Fr, ELISA, WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human ITGA7. The exact immunogen used to generate this antibody is proprietary information.

Q13683

Specificity

ab75224 detects endogenous levels of a fragment of activated ITGA7 resulting from cleavage adjacent to Glu959.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "IHCP" : {"fullname" : "Immunohistochemistry paraffin embedded sections", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "See Abreview.", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "African green monkey": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "for the full length protein.", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "See Abreview.", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

Purification 관련 사항

ab75224 affinity purified from rabbit antiserum by affinity chromatography usingan epitope specific immunogen.

보관 버퍼

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ITGA7 also known as integrin alpha 7 is a transmembrane protein that plays an important role in cell adhesion and signaling. Weighing approximately 124 kDa ITGA7 is part of the integrin family of proteins functioning as a receptor that binds primarily to extracellular matrix proteins such as laminins. It is expressed largely in skeletal and cardiac muscle tissues but research shows its presence in other tissues like the nervous system.

Biological function summary

ITGA7 interacts with the beta-1 integrin subunit to form a heterodimeric receptor. This combination mediates cell-matrix adhesion promoting cell migration differentiation and survival. ITGA7 is also involved in the stabilization of mature muscle cells and development of muscle fibers. By engaging with specific laminin isoforms ITGA7 influences tissue architecture and function.

Pathways

Researchers recognize that ITGA7 is important in signaling pathways like the PI3K/Akt pathway which affects cell growth and survival. ITGA7 interacts with proteins like focal adhesion kinase (FAK) to transmit signals from the extracellular matrix to the inside of the cell. This communication helps regulate cellular responses and adaptability in dynamic environments.

ITGA7 has connections to muscular dystrophy and certain types of cancer. Mutations or altered expression of ITGA7 can lead to muscular dystrophy where muscle function becomes compromised. In cancer altered ITGA7 expression may affect tumor progression and metastasis with connections to proteins such as dystroglycan. Understanding these relationships is essential for developing targeted therapeutic interventions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as a Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.

See full target information ITGA7

대체 명칭 보기

UNQ406/PRO768, ITGA7, Integrin alpha-7

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제품이 사용된 논문 (6)

Recent publications for all applications. Explore the 전체 목록 and refine your search

iScience 27:109351 PubMed38495825

2024

Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Shan Gao,Wei Yao,Rui Zhou,Zuowei Pei

Journal of the American Heart Association 11:e026494 PubMed36444867

2022

Integrin α7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Enrico Bugiardini,Andreia M Nunes,Ariany Oliveira-Santos,Marisela Dagda,Tatiana M Fontelonga,Pamela Barraza-Flores,Alan M Pittman,Jasper M Morrow,Matthew Parton,Henry Houlden,Perry M Elliott,Petros Syrris,Roderick P Maas,Mohammed M Akhtar,Benno Küsters,Joost Raaphorst,Meyke Schouten,Erik-Jan Kamsteeg,Baziel van Engelen,Michael G Hanna,Rahul Phadke,Luis R Lopes,Emma Matthews,Dean J Burkin

British journal of cancer 125:983-993 PubMed34253873

2021

Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response.

Applications

Unspecified application

Species

Unspecified reactive species

Noha Gwili,Stacey J Jones,Waleed Al Amri,Ian M Carr,Sarah Harris,Brian V Hogan,William E Hughes,Baek Kim,Fiona E Langlands,Rebecca A Millican-Slater,Arindam Pramanik,James L Thorne,Eldo T Verghese,Geoff Wells,Mervat Hamza,Layla Younis,Nevine M F El Deeb,Thomas A Hughes

Development (Cambridge, England) 146: PubMed31371375

2019

Laminin α2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development.

Applications

Unspecified application

Species

Unspecified reactive species

Maqsood Ahmed,Leandro N Marziali,Ernest Arenas,M Laura Feltri,Charles Ffrench-Constant

American journal of physiology. Regulatory, integr 306:R837-44 PubMed24671243

2014

Chronic binge alcohol consumption alters myogenic gene expression and reduces in vitro myogenic differentiation potential of myoblasts from rhesus macaques.

Applications

Unspecified application

Species

Unspecified reactive species

Liz Simon,Nicole LeCapitaine,Paul Berner,Curtis Vande Stouwe,Jason C Mussell,Timothy Allerton,Stefany D Primeaux,Jason Dufour,Steve Nelson,Gregory J Bagby,William Cefalu,Patricia E Molina

Molecular therapy : the journal of the American So 21:520-5 PubMed23319059

2013

AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice.

Applications

Unspecified application

Species

Human

Kristin N Heller,Chrystal L Montgomery,Paul Ml Janssen,K Reed Clark,Jerry R Mendell,Louise R Rodino-Klapac

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ITGA7 antibody

Western blot - Anti-ITGA7 antibody (AB75224)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (6)

Product promise