AB104550

Anti-ITPR2 antibody

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(2 제품이 사용된 논문 )

Goat Polyclonal ITPR2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Inositol 1,4,5-trisphosphate receptor type 2 aa 1150 to C-terminus.

대체 명칭 보기

IP3 receptor isoform 2, IP3R 2, InsP3R2, Type 2 InsP3 receptor, ITPR2

3 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

ab104550 at 3.75μg/ml staining ITPR2 in Human heart by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

ab104550 at 3.75μg/ml staining ITPR2 in Human skin by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

ab104550 at 3.75μg/ml staining ITPR2 in Human kidney by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

주요 정보

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Inositol 1,4,5-trisphosphate receptor type 2 aa 1150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q14571

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3.75 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The type 2 inositol 145-trisphosphate receptor (ITPR2) acts as a channel for calcium ions. This receptor is also known as IP3R2 and weighs approximately 313 kDa. It consists of six transmembrane domains. ITPR2 enables the release of calcium from the endoplasmic reticulum into the cytosol. ITPR2 is expressed mostly in the brain heart and testis although its expression can vary in other tissues according to physiological needs.

Biological function summary

ITPR2 regulates intracellular calcium signaling. Calcium ions serve as second messengers in a variety of cellular processes. ITPR2 forms a functional tetrameric complex which increases its functional diversity. This complex plays a role in neuronal communication muscle contraction and various cellular signaling pathways like cell growth.

Pathways

ITPR2 participates actively in the calcium signaling pathway. It closely associates with proteins such as calmodulin that mediate cellular responses. ITPR2 is also central to the phosphoinositide pathway where it links with phospholipase C to initiate downstream effects. These pathways impact diverse physiological functions by modulating intracellular calcium levels.

Abnormal function of ITPR2 links to neurodegenerative diseases such as Alzheimer's disease. It can lead to disrupted calcium homeostasis affecting neuronal viability. ITPR2 also associates with cardiac hypertrophy where calcium imbalance impairs cardiac cell function. Interactions with proteins like amyloid-beta in Alzheimer's contribute to its pathological role. Understanding these interactions could offer targets for therapeutic intervention.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity).

See full target information Inositol 1,4,5-trisphosphate receptor type 2

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of molecular and cellular cardiology 179:47-59 PubMed37003353

2023

InsPR-RyR channel crosstalk augments sarcoplasmic reticulum Ca release and arrhythmogenic activity in post-MI pig cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Jin,Anna Meletiou,Joshua Chung,Agne Tilunaite,Kateryna Demydenko,Eef Dries,Rosa Doñate Puertas,Matthew Amoni,Ashutosh Tomar,Guillaume Gilbert,Piet Claus,Christian Soeller,Vijay Rajagopal,Karin Sipido,H Llewelyn Roderick

BioMed research international 2014:395781 PubMed24563864

2014

Direct cell-cell contact between mesenchymal stem cells and endothelial progenitor cells induces a pericyte-like phenotype in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Markus Loibl,Andreas Binder,Marietta Herrmann,Fabian Duttenhoefer,R Geoff Richards,Michael Nerlich,Mauro Alini,Sophie Verrier

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ITPR2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise