AB252960

Anti-JWA antibody

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Rabbit Polyclonal JWA antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARL6IP5 aa 50-150.

대체 명칭 보기

DERP11, JWA, PRA2, PRAF3, HSPC127, ARL6IP5, PRA1 family protein 3, ADP-ribosylation factor-like protein 6-interacting protein 5, Cytoskeleton-related vitamin A-responsive protein, Dermal papilla-derived protein 11, GTRAP3-18, Glutamate transporter EAAC1-interacting protein, JM5, Prenylated Rab acceptor protein 2, Protein JWa, Putative MAPK-activating protein PM27, ARL-6-interacting protein 5, Aip-5

3 이미지

Immunocytochemistry/ Immunofluorescence - Anti-JWA antibody (AB252960)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-JWA antibody (AB252960)

PFA-fixed, Triton X-100 permeabilized U-251MG (Human brain glioma cell line) cells stained for JWA (green) using ab252960 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JWA antibody (AB252960)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JWA antibody (AB252960)

Paraffin-embedded human duodenum tissue stained for JWA using ab252960 at 1/50 dilution in immunohistochemical analysis.

Unknown

Western blot - Anti-JWA antibody (AB252960)

All lanes:

Western blot - Anti-JWA antibody (ab252960) at 1/200 dilution

All lanes:

Human cell line RT-4 at 0.4 µg/mL

Predicted band size: 22 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ARL6IP5 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

O75915

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "Fixation/Permeabilization: PFA/Triton X-100." }, "Macaque monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

JWA also known as GTRAP3-18 or ADDCL is a protein with a molecular mass of approximately 37 kDa. Mechanically JWA functions in detoxification processes as it enhances the capacity of cells to combat oxidative stress. This protein exhibits a wide expression pattern across various tissues including the liver and the nervous system. JWA operates in both the cytoplasm and nucleus and dynamically shuttles between these cellular compartments.

Biological function summary

JWA interacts with signaling molecules to modulate cellular responses particularly in stress and repair processes. As a part of multi-protein complexes it collaborates with components like ERK (extracellular signal-regulated kinase) to influence cell survival and proliferation. JWA's involvement extends to regulating cytoskeletal elements affecting cellular movements important for tissue repair and immune responses.

Pathways

JWA integrates into the MAPK/ERK signaling pathway and the ATRA (all-trans retinoic acid) pathway. In these pathways JWA associates with proteins such as MEK1/2 and enhances their activity to promote cell differentiation and combat cellular apoptosis. The interaction of JWA with protein kinases exhibits its integral role in transmitting signaling molecules' instructions necessary for cellular development processes.

JWA shows a connection to cancer and neurodegenerative disorders. In cancer biology JWA's modulation of signaling pathways affects tumor growth interacting with proteins like p53 to induce cell cycle arrest and apoptosis. In the context of neurodegenerative disorders JWA helps mitigate oxidative stress and interacts with proteins involved in neuronal integrity suggesting a protective role against conditions like Alzheimer's disease.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum.

See full target information ARL6IP5

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 16:6876 PubMed40715139

2025

The mechanotransducer Piezo1 coordinates metabolism and inflammation to promote skin growth.

Applications

Unspecified application

Species

Unspecified reactive species

Yingchao Xue,Elizabeth Winnicki,Zhaoxu Zhang,Ines Lopez,Saifeng Wang,Charles Kirby,Sam S Lee,Ang Li,Chaewon Lee,Hana Minsky,Kaitlin Williams,Kevin Yueh-Hsun Yang,Ling He,Sashank K Reddy,Luis A Garza

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-JWA antibody

Immunocytochemistry/ Immunofluorescence - Anti-JWA antibody (AB252960)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JWA antibody (AB252960)

Western blot - Anti-JWA antibody (AB252960)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise