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AB281189

Anti-Kallikrein 6 antibody [EPR23352-86] - BSA and Azide free (Capture)

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Rabbit Recombinant Monoclonal Kallikrein 6 antibody. Carrier free. Suitable for sELISA and reacts with Human samples.
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Sandwich ELISA - Anti-Kallikrein 6 antibody [EPR23352-86] - BSA and Azide free (Capture) (AB281189)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-Kallikrein 6 antibody [EPR23352-86] - BSA and Azide free (Capture) (AB281189)

Example of Human Kallikrein 6/KLK6 standard curve. Background-subtracted data values (mean +/- SD) are graphed.

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR23352-86

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Assay Kits

AB287163

Human Kallikrein 6/KLK6 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Kallikrein 6/KLK6 ELISA Kit (AB287163)

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Sample Prep & Detection Kits

AB201798

DyLight® 405 Conjugation Kit (Fast) - Lightning-Link®

Schematic Diagram - DyLight® 405 Conjugation Kit (Fast) - Lightning-Link® (AB201798)

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Sample Prep & Detection Kits

AB188215

Gold Conjugation Kit (20 nm, 20 OD)

Conjugation - Gold Conjugation Kit (20 nm, 20 OD) (AB188215)

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Primary Antibodies

AB244967

Anti-IGFBP7 antibody [EPR20485-100] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-IGFBP7 antibody [EPR20485-100] - BSA and Azide free (Detector) (AB244967)

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Primary Antibodies

AB281230

Anti-NPTX2 antibody [EPR24020-169] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-NPTX2 antibody [EPR24020-169] - BSA and Azide free (Capture) (AB281230)

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Primary Antibodies

AB242600

Anti-PARK7/DJ1 antibody [EPR19466-1] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-PARK7/DJ1 antibody [EPR19466-1] - BSA and Azide free (Capture) (AB242600)

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  • 0
Primary Antibodies

AB259649

Anti-PDGFR beta antibody [EPR22290-256] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-PDGFR beta antibody [EPR22290-256] - BSA and Azide free (Capture) (AB259649)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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제품 세부 정보

ab281189 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human KLK6. The recommended pair for sandwich ELISA is:
Capture: ab281189, Human KLK6 Capture Antibody (unconjugated)
Detector: ab281039, Human KLK6 Detector Antibody (unconjugated)
The reference range value is 7.8 - 500 pg/mL.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Kallikrein 6 also known as KLK6 is a serine protease with notable enzymatic properties. This protein part of the kallikrein family weighs approximately 25 kDa and exhibits chymotrypsin-like activity. KLK6 is highly expressed in the central nervous system and various body fluids such as cerebrospinal fluid and milk. Due to this distribution KLK6 may play roles in neurological and physiological processes.
Biological function summary

KLK6 participates in the degradation of extracellular matrix components. It functions within complex proteolytic cascades facilitating tissue remodeling and repair. Additionally KLK6 interacts with other kallikreins like kallikrein 3 showing intricate regulation within the kallikrein-related peptidase network. This interplay points toward its importance in modulating extracellular environment and cellular interactions.

Pathways

KLK6 engages in the neurogenic and inflammatory response pathways. It ties into MAPK signaling influencing processes such as cell proliferation and apoptosis. Through these pathways KLK6 associates with proteins like MMPs which modulate extracellular matrix dynamics. Its presence in these pathways positions KLK6 as a significant regulatory protein during cellular homeostasis and stress responses.

KLK6 correlates with neurodegenerative diseases like Alzheimer's and multiple sclerosis. Altered expression and activity levels of KLK6 have implications for disease progression and pathology. In Alzheimer's KLK6 may influence amyloid-beta processing connecting with proteins like APP. In multiple sclerosis KLK6 affects demyelination processes showing potential interactions with myelin-associated proteins. Understanding these relationships can guide therapeutic strategies targeting KLK6-related pathways.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
See full target information KLK6

대체 명칭 보기

PRSS18, PRSS9, KLK6, Kallikrein-6, Neurosin, Protease M, SP59, Serine protease 18, Serine protease 9, Zyme
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Product promise

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