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AB244367

Anti-Kallikrein 7/KLK7 antibody

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Rabbit Polyclonal Kallikrein 7/KLK7 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human KLK7 aa 100 to C-terminus.

대체 명칭 보기

PRSS6, SCCE, KLK7, Kallikrein-7, hK7, Serine protease 6, Stratum corneum chymotryptic enzyme, hSCCE

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-Kallikrein 7/KLK7 antibody (AB244367)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Kallikrein 7/KLK7 antibody (AB244367)

PFA fixed, Triton X-100 permeabilized HaCat (Human keratinocyte cell line) cells labeling Kallikrein 7/KLK7 using ab244367 at 4 μg/ml (green) in ICC/IF.

Western blot - Anti-Kallikrein 7/KLK7 antibody (AB244367)
  • WB

Unknown

Western blot - Anti-Kallikrein 7/KLK7 antibody (AB244367)

All lanes:

Western blot - Anti-Kallikrein 7/KLK7 antibody (ab244367) at 0.4 µg/mL

Lane 1:

Vector only transfected HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) lysate

Lane 2:

Kallikrein 7/KLK7 overexpression HEK-293T cell lysate

Predicted band size: 28 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human KLK7 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P49862

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대체품

Primary Antibodies

AB96710

Anti-Kallikrein 7/KLK7 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 7/KLK7 antibody (AB96710)

  • 0
  • 0
Primary Antibodies

AB200745

Anti-Kallikrein 7/KLK7 antibody

Western blot - Anti-Kallikrein 7/KLK7 antibody (AB200745)

  • 0
  • 0
Primary Antibodies

AB254258

Anti-Kallikrein 7/KLK7 antibody [EPR22594-203]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 7/KLK7 antibody [EPR22594-203] (AB254258)

  • 0
  • 0
Primary Antibodies

AB255328

Anti-Kallikrein 7/KLK7 antibody [EPR22594-203] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 7/KLK7 antibody [EPR22594-203] - BSA and Azide free (AB255328)

  • 0
  • 0

보완 제품

Assay Kits

AB287175

Human Kallikrein 7/KLK7 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Kallikrein 7/KLK7 ELISA Kit (AB287175)

  • 0
  • 0
Primary Antibodies

AB221099

Anti-IRF2BPL antibody

Immunocytochemistry/ Immunofluorescence - Anti-IRF2BPL antibody (AB221099)

  • 0
  • 0
Primary Antibodies

AB156769

Anti-CD163 antibody [OTI2G12]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD163 antibody [OTI2G12] (AB156769)

  • 5
  • 5
Primary Antibodies

AB8878

Anti-CD11b antibody [M1/70]

Lab Essentials|Recombinant

Flow Cytometry - Anti-CD11b antibody [M1/70] (AB8878)

  • 4
  • 17
Primary Antibodies

AB190924

Anti-Kallikrein 6 antibody - C-terminal

Immunocytochemistry/ Immunofluorescence - Anti-Kallikrein 6 antibody - C-terminal (AB190924)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Kallikrein 7 also known as KLK7 is a serine protease enzyme active in the skin. The protein's mass is approximately 27 kDa. It helps in the desquamation process by breaking down corneodesmosomes which are cell structures that facilitate cell adhesion in the outer skin layer. Kallikrein 7 is highly expressed in the epidermis and various mucosal surfaces reflecting its essential role in maintaining skin barrier functions.
Biological function summary

KLK7 contributes to skin homeostasis and renewal processes. Its enzymatic action involves cleaving proteins like desmoglein and corneodesmosin which are part of the desmosomal complex. This activity promotes the natural shedding of skin cells a process important for skin turnover and repair. By regulating this balance KLK7 supports not only skin health but also its resilience against external stressors.

Pathways

KLK7 plays a significant role in processes such as the proteolytic cascade and inflammation. It is involved in the kallikrein-kinin system alongside proteins like KLK5 that modulate inflammatory responses and barrier function in skin. KLK7 also interacts with pathways related to tissue remodeling influencing processes like inflammation through cytokine activation.

KLK7 is linked to skin conditions like atopic dermatitis and psoriasis. These disorders often feature a disrupted skin barrier where KLK7-mediated proteolytic activity increases and may exacerbate inflammation. The relationship with inflammation also connects KLK7 to proteins such as KLK5 which can further intensify skin disorders when their activities are unregulated.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
See full target information KLK7
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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