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AB239220

Anti-KATNAL2 antibody

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Goat Polyclonal KATNAL2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KATNAL2 aa 100-200.

대체 명칭 보기

Katanin p60 ATPase-containing subunit A-like 2, Katanin p60 subunit A-like 2, p60 katanin-like 2, KATNAL2

주요 정보

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human KATNAL2 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q8IYT4

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대체품

Primary Antibodies

AB184829

Anti-KATNAL2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KATNAL2 antibody (AB184829)

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보완 제품

Primary Antibodies

AB111881

Anti-p60 katanin antibody [EPR5071]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-p60 katanin antibody [EPR5071] (AB111881)

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Primary Antibodies

AB82422

Anti-KATNAL1 antibody

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Primary Antibodies

AB3475

Anti-Kif2a antibody

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Primary Antibodies

AB70841

Anti-FIGNL1 antibody

Immunoprecipitation - Anti-FIGNL1 antibody (AB70841)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.3 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

KATNAL2 also known by its official full name Katanin catalytic subunit A-like 2 is a protein involved in microtubule severing. It possesses a molecular mass of approximately 63 kDa. KATNAL2 is expressed in various tissues throughout the body with notable expression in the brain and reproductive organs. This protein is important for the regulation of the cytoskeleton through the disassembly of microtubules contributing to cellular structure maintenance.
Biological function summary

KATNAL2 plays a role in cellular processes like mitosis and neuronal development. As part of a larger protein complex it interacts with other proteins to facilitate its microtubule severing activity. This action helps in remodeling the microtubule network which is essential for cellular dynamics and morphological changes during cell division and differentiation. The precise assembly and disassembly controlled by KATNAL2 are important for ensuring normal cell function and development.

Pathways

KATNAL2 associates with the microtubule dynamics pathway and is involved in mitotic spindle organization. It interacts with proteins such as katanin p60 which assists in severing microtubules. This interaction allows for the correct segregation of chromosomes during cell division. Additionally KATNAL2 may influence signaling pathways related to cytoskeletal organization demonstrating its importance in maintaining cellular integrity.

Changes in KATNAL2 function link to neurodevelopmental disorders and male infertility. Abnormal expression levels of KATNAL2 have implications in conditions affecting neuronal development where its role alongside proteins such as the tubulin family becomes apparent. Disruption in these pathways related to KATNAL2 can lead to disorders characterized by improper neuronal connections or alterations in testicular structure leading to infertility. Understanding KATNAL2's interaction with related proteins sheds light on its impact on these diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
See full target information KATNAL2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in molecular neuroscience 18:1552819 PubMed40206188

2025

The restoration of REST inhibits reactivity of Down syndrome iPSC-derived astrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Tan Huang,Sharida Fakurazi,Pike-See Cheah,King-Hwa Ling
제품이 사용된 논문 모두 보기
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Product promise

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