AB88752

Anti-Kazrin antibody

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Mouse Polyclonal Kazrin antibody. Carrier free. Suitable for WB and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KAZN.

2 이미지

Unknown

Western blot - Anti-Kazrin antibody (AB88752)

All lanes:

Western blot - Anti-Kazrin antibody (ab88752) at 1 µg/mL

All lanes:

Rat brain tissue lysate at 50ug/lane

Predicted band size: 86 kDa

Observed band size: 45 kDa,86 kDa

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Unknown

Western blot - Anti-Kazrin antibody (AB88752)

All lanes:

Western blot - Anti-Kazrin antibody (ab88752) at 1 µg/mL

Lane 1:

Kazrin transfected 293T cell lysate (45.65 kDa) at 25ug/lane

Lane 2:

Non-transfected 293T cell lysate at 25ug/lane

Predicted band size: 86 kDa

Observed band size: 60 kDa

false

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Rat, Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human KAZN.

Q674X7

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.4 Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Kazrin also known as KAZ is a multifunctional protein involved in several cellular processes. It has an approximate mass of 55 kDa and is expressed in a variety of tissues including skin hair follicles and the cytoplasm of epithelial cells. Kazrin interacts with various proteins influencing cell adhesion proliferation and differentiation. Scientists also study its role in cytoskeletal organization as it binds to cytoskeletal proteins and contributes to cellular structure integrity.

Biological function summary

Kazrin plays a significant role in the maintenance of skin barrier function and epidermal differentiation. It is part of a complex that includes desmosomal and cytoskeletal proteins which together ensure proper cell-cell adhesion. These interactions assist in maintaining the mechanical stress response in tissues therefore contributing to tissue homeostasis. Kazrin influences epithelial morphogenesis and wound healing by modulating the dynamics and organization of actin filaments.

Pathways

Several biological pathways feature Kazrin due to its involvement in cellular adhesion and organization. Notably it participates in the keratinocyte differentiation pathway and cadherin signaling. Within these pathways it interacts with proteins such as desmoplakin and plakophilins which are essential for desmosome assembly and function. By regulating these interactions Kazrin supports the mechanical strength and resilience of cellular structures.

Dysregulation of Kazrin associates with certain skin-related conditions and cancers. Abnormal expression levels can impact epidermolysis bullosa a group of heritable skin blistering disorders by affecting the stability and function of desmosome components. Additionally Kazrin’s interaction with p53 a well-known tumor suppressor protein links it to various cancer progressions. Researchers continue to explore these connections to understand better Kazrin's role in disease mechanisms and potential therapeutic targets.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.

See full target information KAZN

대체 명칭 보기

C1orf196, KAZ, KIAA1026, HRIHFB2003, KAZN, Kazrin

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of cell science 130:2251-2265 PubMed28536105

2017

TRAPPC13 modulates autophagy and the response to Golgi stress.

Applications

Unspecified application

Species

Unspecified reactive species

Silvia Ramírez-Peinado,Tatiana I Ignashkova,Bram J van Raam,Jan Baumann,Erica L Sennott,Mathieu Gendarme,Ralph K Lindemann,Michael N Starnbach,Jan H Reiling

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Kazrin antibody

Western blot - Anti-Kazrin antibody (AB88752)

Western blot - Anti-Kazrin antibody (AB88752)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (1)

Product promise