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AB66640

Anti-KCNQ3 antibody

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(4 제품이 사용된 논문 )

Rabbit Polyclonal KCNQ3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human KCNQ3.
1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KCNQ3 antibody (AB66640)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KCNQ3 antibody (AB66640)

IHC image of ab66640 staining in human colon formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab66640, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human KCNQ3. The exact immunogen used to generate this antibody is proprietary information.

O43525

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보완 제품

Primary Antibodies

AB22897

Anti-KCNQ2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-KCNQ2 antibody (AB22897)

  • 4
  • 5
Primary Antibodies

AB133534

Anti-Rad51 antibody [EPR4030(3)]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Rad51 antibody [EPR4030(3)] (AB133534)

  • 4
  • 15
Reagents, Controls & Accessories

AB93684

Antigen Retrieval Buffer (100X Tris-EDTA Buffer, pH 9.0)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Antigen Retrieval Buffer (100X Tris-EDTA Buffer, pH 9.0) (AB93684)

  • 5
  • 3
Primary Antibodies

AB192025

Anti-HCN3 antibody [EPR13494(2)]

RabMAb|Recombinant

Immunoprecipitation - Anti-HCN3 antibody [EPR13494(2)] (AB192025)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed : 16319223, PubMed : 27564677, PubMed : 28793216, PubMed : 9872318). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed : 14534157, PubMed : 16319223, PubMed : 27564677, PubMed : 9872318). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed : 14534157, PubMed : 16319223, PubMed : 28793216). M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed : 28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed : 28793216). Suppressed by activation of M1 muscarinic acetylcholine receptors (PubMed : 10713961). KCNQ3 also associates with KCNQ5 to form a functional channel in vitro and may also contribute to the M-current in brain (PubMed : 11159685).
See full target information KCNQ3

대체 명칭 보기

Potassium voltage-gated channel subfamily KQT member 3, KQT-like 3, Potassium channel subunit alpha KvLQT3, Voltage-gated potassium channel subunit Kv7.3, KCNQ3
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of clinical medicine 12: PubMed37048724

2023

Comparative Transcriptomic Analysis of Archival Human Vestibular Schwannoma Tissue from Patients with and without Tinnitus.

Applications

Unspecified application

Species

Unspecified reactive species

Krishna Bommakanti,Richard Seist,Phanidhar Kukutla,Murat Cetinbas,Shelley Batts,Ruslan I Sadreyev,Anat Stemmer-Rachamimov,Gary J Brenner,Konstantina M Stankovic

Science advances 8:eabo3625 PubMed35857840

2022

Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine.

Applications

Unspecified application

Species

Unspecified reactive species

Nien-Du Yang,Richard Kanyo,Lu Zhao,Jingru Li,Po Wei Kang,Alex Kelly Dou,Kelli McFarland White,Jingyi Shi,Jeanne M Nerbonne,Harley T Kurata,Jianmin Cui

Neuron 106:649-661.e4 PubMed32197063

2020

Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Veronica C Galvin,Sheng Tao Yang,Constantinos D Paspalas,Yang Yang,Lu E Jin,Dibyadeep Datta,Yury M Morozov,Taber C Lightbourne,Adam S Lowet,Pasko Rakic,Amy F T Arnsten,Min Wang

PloS one 13:e0192122 PubMed29579054

2018

The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohong Wei,Yujiao Zhang,Benlan Yin,Jing Wen,Jun Cheng,Xiaodong Fu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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