AB126329

Anti-Keratin 77 antibody

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Rabbit Polyclonal K2C1B antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KRT77.

대체 명칭 보기

KRT1B, KRT77, Cytokeratin-1B, Keratin-77, Type-II keratin Kb39, CK-1B, K77

1 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Keratin 77 antibody (AB126329)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Keratin 77 antibody (AB126329)

ab126329 at 1/200 dilution staining Keratin 77 in paraffin-embedded Human skin tissue by Immunohistochemistry.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human KRT77. The exact immunogen used to generate this antibody is proprietary information.

Q7Z794

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Keratin 77 also known as KRT77 or CYK17 is a type of keratin protein that plays a structural role in epithelial cells. This protein weighs approximately 56 kDa and is mainly expressed in the suprabasal layers of the epidermis and in hair follicles where it contributes to the formation and maintenance of cellular integrity. Keratin 77 belongs to the type II keratin family which pairs with type I keratins to form intermediate filaments essential for cell stability and resilience against mechanical stress.

Biological function summary

Keratin 77 functions as a critical component in skin barrier function and keratinocyte differentiation. It integrates into complex networks of intermediate filaments that provide tensile strength to cells. This keratin participates in maintaining the rigidity and elasticity of the skin by combining with other keratins like KRT5 and KRT14 constituting a keratin filament complex necessary for proper skin function. The presence of keratin 77 in hair follicles also suggests a role in hair structure and growth.

Pathways

Keratin 77 is deeply involved in several skin differentiation and repair pathways. It interacts with proteins such as filaggrin and loricrin in the epidermal differentiation complex supporting the skin barrier's protective function. In the wound healing pathway keratin 77 modulates cellular response and organization within the epidermis working alongside proteins like involucrin to facilitate skin repair processes.

Mutations or deficiencies in keratin 77 have associations with skin-related conditions including dermatitis and pachyonychia congenita. In dermatitis abnormal keratin 77 expression affects skin barrier function potentially exacerbating inflammatory responses. Additionally the role of keratin 77 in pachyonychia congenita links it to nail dystrophies where it interacts with keratins such as KRT16 and KRT6A contributing to the clinical manifestations of this disorder.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information KRT77

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell death & disease 15:681 PubMed39289348

2024

MANF serves as a novel hepatocyte factor to promote liver regeneration after 2/3 partial hepatectomy via doubly targeting Wnt/β-catenin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yanyan Liang,Qiong Mei,Enguang He,Petek Ballar,Chuansheng Wei,Yue Wang,Yue Dong,Jie Zhou,Xiaofang Tao,Wenyan Qu,Mingxia Zhao,Goma Chhetri,Limeng Wei,Juntang Shao,Yujun Shen,Jun Liu,Lijie Feng,Yuxian Shen

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Keratin 77 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Keratin 77 antibody (AB126329)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise