AB236507

Anti-KLF2 antibody [OTI5F1]

Name: Anti-KLF2 antibody [OTI5F1]
Brand: Abcam Limited
SKU: AB236507
Rating: 1 (1 reviews)

(1 리뷰)

(10 제품이 사용된 논문 )

Mouse Monoclonal KLF2 antibody. Suitable for WB and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KLF2.

대체 명칭 보기

LKLF, KLF2, Krueppel-like factor 2, Lung krueppel-like factor

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI5F1

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human KLF2.

Q9Y5W3

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" } } }

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제품 세부 정보

Clone OTI5F1 (formerly 5F1).

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification

Purification 관련 사항

Purified from cell culture supernatant.

보관 버퍼

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

KLF2 also known as Kruppel-like factor 2 is a transcription factor with a molecular mass of approximately 37 kDa. It belongs to the Kruppel-like family of transcription factors which share zinc finger domains. KLF2 regulates gene expression by binding to specific DNA sequences in promoters influencing cellular processes. Researchers have localized its expression predominantly in the vascular endothelium the lungs and the spleen. In these tissues KLF2 influences endothelial cell function and vascular biology.

Biological function summary

KLF2 mediates cellular processes including endothelial cell maintenance and vascular development. As a transcription factor KLF2 does not operate as part of a multi-protein complex but rather performs its regulatory function individually by modulating target gene expression. KLF2 activates genes associated with anti-inflammatory and anti-thrombotic properties in endothelial cells contributing to vascular homeostasis. Its role is key in maintaining the balance between pro- and anti-inflammatory signals in the vascular system.

Pathways

KLF2 integrates its function into various signaling pathways notably the MEK/ERK and PI3K/Akt pathways. KLF2 modulates these pathways to control proliferation differentiation and apoptosis in endothelial cells. In particular KLF2-induced gene expression influences these pathways by interacting with other proteins such as MEK and ERK proteins that regulate cell survival and inflammatory responses. These interactions highlight the relevance of KLF2 in cellular signaling important for vascular health.

KLF2 has significant implications for cardiovascular diseases and atherosclerosis. Research associates KLF2 with protective roles against the development of atherosclerosis due to its influence on endothelial function and inflammation. When KLF2 expression is compromised the risk for thrombosis and vascular inflammation increases contributing to cardiovascular conditions. Additionally studies link KLF2 to the pathophysiology of diabetes where aberrant KLF2 expression disrupts normal endothelial functions exacerbating diabetic complications. KLF2 interacts with proteins like NF-kB in such conditions impacting the expression of genes involved in inflammation and metabolism.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed : 21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed : 28167758).

See full target information KLF2

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제품이 사용된 논문 (10)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Arthritis research & therapy 26:222 PubMed39702240

2024

KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus.

Applications

Unspecified application

Species

Unspecified reactive species

Hongshuai Zhao,Zaichuan Lin,Peiwen Zhang,Jiayue Rao,Shumin Xu,Qing Luo,Junming Li

Archives of medical science : AMS 20:918-937 PubMed39050179

2024

Enhancing postmenopausal osteoporosis: a study of KLF2 transcription factor secretion and PI3K-Akt signaling pathway activation by PIK3CA in bone marrow mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjie Ma,Chen Li

Aging 16:4138-4148 PubMed38462692

2024

Azilsartan improves urinary albumin excretion in hypertension mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Cao,Dandan Zhang,Wenfeng Li,Wenjin Yuan,Gang Luo,Shaofeng Xie

Frontiers in molecular biosciences 10:1176267 PubMed37325477

2023

Single-cell RNA-seq uncovers distinct pathways and genes in endothelial cells during atherosclerosis progression.

Applications

Unspecified application

Species

Unspecified reactive species

Min Wu,Yijin Wu,Shulin Tang,Jinsong Huang,Yueheng Wu

Open life sciences 18:20220587 PubMed37077343

2023

Shear stress leads to the dysfunction of endothelial cells through the Cav-1-mediated KLF2/eNOS/ERK signaling pathway under physiological conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Lihua Wang,Bingyue Wang,Lan Jia,Haibo Yu,Zhe Wang,Fang Wei,Aili Jiang

Journal of thoracic disease 15:1247-1257 PubMed37065597

2023

-mediated m6A mRNA modification of suppresses cisplatin resistance in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xifan Wang,Yu'an Hu,Xiaoqing Li,Chuandong Zhu,Fangfang Chen

Experimental and therapeutic medicine 24:737 PubMed36478888

2022

KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Tan,Hongqiang Ren,Yijun Liu,Hanxuan Yang,Qian Luo,Xuejun Deng

Molecular medicine reports 26: PubMed35674157

2022

Role of TRIM22 in ulcerative colitis and its underlying mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Ye,Zhongkai Lu

Bioengineered 12:8476-8484 PubMed34565285

2021

Montelukast attenuates interleukin IL-1β-induced oxidative stress and apoptosis in chondrocytes by inhibiting CYSLTR1 (Cysteinyl Leukotriene Receptor 1) and activating KLF2 (Kruppel Like Factor 2).

Applications

Unspecified application

Species

Unspecified reactive species

Zongwei Li,Jianming Wang,Yumin Ma

Aging 13:12996-13005 PubMed33946046

2021

Azilsartan ameliorates ox-LDL-induced endothelial dysfunction via promoting the expression of KLF2.

Applications

Unspecified application

Species

Unspecified reactive species

Wenfeng Li,Chenggao Wang,Dandan Zhang,Kanghua Zeng,Shihui Xiao,Feng Chen,Jun Luo

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-KLF2 antibody [OTI5F1]

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (10)

Product promise