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AB221867

Anti-KLF8 antibody

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Rabbit Polyclonal KLF8 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human KLF8 aa 50-150.

대체 명칭 보기

BKLF3, ZNF741, KLF8, Krueppel-like factor 8, Basic krueppel-like factor 3, Zinc finger protein 741

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-KLF8 antibody (AB221867)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-KLF8 antibody (AB221867)

PFA-fixed, Triton X-100 permeabilized RT4 (human urinary bladder cancer cell line) cells stained for KLF8 (green) using ab221867 at 4 μg/ml in ICC/IF.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human KLF8 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

O95600

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대체품

Primary Antibodies

AB168527

Anti-KLF8 antibody

Immunocytochemistry/ Immunofluorescence - Anti-KLF8 antibody (AB168527)

  • 0
  • 0

보완 제품

Primary Antibodies

AB67790

Anti-KIF16B antibody

  • 0
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Primary Antibodies

AB314109

Anti-KLF5 antibody [BLR243L] - BSA free

KO Validated|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF5 antibody [BLR243L] - BSA free (AB314109)

  • 0
  • 0
Primary Antibodies

AB109737

Anti-Dlx5 antibody [EPR4488]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dlx5 antibody [EPR4488] (AB109737)

  • 0
  • 0
Primary Antibodies

AB283650

Anti-Id1 antibody [EPR24304-18A]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Id1 antibody [EPR24304-18A] (AB283650)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

KLF8 also known as Kruppel-like factor 8 is a transcription factor involved in regulating gene expression. It contains a zinc finger DNA-binding domain typical for the KLF family and weighs approximately 38 kDa. KLF8 expresses in several tissues with significant presence in kidney lung and liver. It shows strong nuclear localization important for its function in the control of transcriptional tone within cells.
Biological function summary

KLF8 regulates cell proliferation differentiation and development. This protein has been associated with a variety of cellular processes often functioning in cell cycle regulation by modulating the expression of genes involved in cell growth. KLF8 does not function as a part of a larger complex but interacts directly with DNA to exert its effects often affecting other KLF family members like KLF4 and KLF5.

Pathways

KLF8 plays an active role in the TGF-beta signaling and Wnt/beta-catenin pathways. It helps orchestrate cellular responses to growth factors by interacting with these pathways affecting processes such as epithelial-mesenchymal transition (EMT). In these pathways KLF8 associates with proteins such as beta-catenin and SMAD3 further emphasizing its role in cellular proliferation and differentiation.

KLF8 is known to relate to cancer and fibrosis. High KLF8 expression levels have been linked to the aggressiveness of certain cancers such as breast cancer and the protein's action influences EMT a critical step in metastasis. In fibrosis KLF8 contributes to pathological tissue remodeling. It connects with other proteins like MMP9 which are involved in matrix remodeling highlighting its significance in disease progression.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).
See full target information KLF8
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Product promise

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