Anti-KLHL13 antibody - N-terminal

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This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

KLHL13 interacts with other proteins to form complexes that regulate cellular processes. It often acts as a substrate adaptor in the Cullin-RING E3 ubiquitin ligase complex. This complex targets specific proteins for degradation maintaining protein homeostasis within the cell. KLHL13 thereby influences various cellular occurrences such as signal transduction and cell cycle control by dictating protein turnover rates.

Pathways

KLHL13 impacts several critical biological pathways involved in cellular maintenance and signaling. Its activity is closely tied to the ubiquitin-proteasome pathway where it ensures the degradation of proteins that could alter cell function if accumulated. KLHL13 also shares functional relationships with other Kelch-like family members emphasizing its role in a network where different family proteins can have overlapping and distinct targets.