AB236393

Anti-Kv beta 1/KCNAB1 antibody [OTI9F7]

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Mouse Monoclonal Kv beta 1/KCNAB1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KCNAB1.

대체 명칭 보기

KCNA1B, KCNAB1, Voltage-gated potassium channel subunit beta-1, K(+) channel subunit beta-1, Kv-beta-1

1 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kv beta 1/KCNAB1 antibody [OTI9F7] (AB236393)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kv beta 1/KCNAB1 antibody [OTI9F7] (AB236393)

Paraffin-embedded human thyroid carcinoma tissue stained for Kv beta 1/KCNAB1 using ab236393 at 1/150 dilution.

Perform heat-induced epitope retrieval using 10 mM citric buffer, pH 6.0 at 100°C for 10 minutes.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI9F7

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human KCNAB1.

Q14722

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Ferret": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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제품 세부 정보

Clone OTI9F7 (formerly 9F7).

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification

Purification 관련 사항

Purified from cell culture supernatant.

보관 버퍼

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Kv beta 1 also known as KCNAB1 is an auxiliary subunit of voltage-gated potassium channels. This protein modulates the functional properties of the Kv channel complex. Kv beta 1 possesses a molecular mass of approximately 44 kDa. It is expressed extensively in the brain and heart where it plays an important role in regulating electrical excitability. By binding to the alpha subunit of the potassium channel Kv beta 1 affects the channel's inactivation dynamics influencing the flow of potassium ions across cell membranes.

Biological function summary

Kv beta 1/KCNAB1 functions as a regulatory component of the Kv channel complex. It interacts with the channel alpha subunits to modify gating properties channel kinetics and response to cellular signals. Kv beta 1 enhances rapid inactivation of certain Kv channels affecting nerve impulse transmission and cardiac muscle contraction. This regulation is essential for maintaining proper action potential shapes and frequencies ensuring appropriate electrical signaling in neurons and cardiac cells.

Pathways

Kv beta 1 is importantly integrated into electrical signaling pathways related to neuronal excitability and cardiac electrical cycle. It is significantly involved in the regulation of the action potential propagation in neurons and myocytes. Kv beta 1 prominently interacts with Kv alpha subunits like Kv1.1 and Kv1.2 affecting their physiological roles and contributing to finely-tuned ion homeostasis during prolonged cellular activities.

Altered Kv beta 1 function associates with certain neurological and cardiac conditions. Dysregulation of this protein's activity links to epilepsy where abnormal neuronal excitability occurs. It is also implicated in cardiac arrhythmias due to its role in cardiac repolarization. Relationships with proteins such as Kv1.1 and Kv1.2 are evident in these conditions suggesting that therapeutic targeting of Kv beta 1 might offer potential benefits in managing these disorders.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed : 17156368, PubMed : 17540341, PubMed : 19713757, PubMed : 7499366, PubMed : 7603988). The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed : 9763623). Promotes the inactivation of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.4/KCNA4, Kv1.5/KCNA5 and Kv1.6/KCNA6 alpha subunit-containing channels (PubMed : 12077175, PubMed : 12130714, PubMed : 15361858, PubMed : 17156368, PubMed : 17540341, PubMed : 19713757, PubMed : 7499366, PubMed : 7603988, PubMed : 7649300, PubMed : 7890764, PubMed : 9763623). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones (By similarity). The binding of NADPH is required for efficient down-regulation of potassium channel activity (PubMed : 17540341). Oxidation of the bound NADPH restrains N-terminal domain from blocking the channel, thereby decreasing N-type inactivation of potassium channel activity (By similarity).. Isoform KvB1.2. Isoform KvB1.2 shows no effect on KCNA1, KCNA2 or KCNB1.

See full target information KCNAB1

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of experimental & clinical cancer research : CR 41:13 PubMed34996491

2022

INPP5F translocates into cytoplasm and interacts with ASPH to promote tumor growth in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qianlei Zhou,Jianhong Lin,Yongcong Yan,Shiyu Meng,Hao Liao,Ruibin Chen,Gui He,Yue Zhu,Chuanchao He,Kai Mao,Jie Wang,Jianlong Zhang,Zhenyu Zhou,Zhiyu Xiao

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Kv beta 1/KCNAB1 antibody [OTI9F7]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kv beta 1/KCNAB1 antibody [OTI9F7] (AB236393)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise