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AB97304

Anti-L3MBTL1 antibody

5

(1 리뷰)

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(2 제품이 사용된 논문 )

Rabbit Polyclonal L3MBTL1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human L3MBTL1 aa 350-750.
1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-L3MBTL1 antibody (AB97304)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-L3MBTL1 antibody (AB97304)

Images show immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, using 1/200 ab97304 alone (1) or merged with DNA probe (2) .

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human L3MBTL1 aa 350-750. The exact immunogen used to generate this antibody is proprietary information.

Q9Y468

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보완 제품

Primary Antibodies

AB17969

Anti-BRD8/p120 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD8/p120 antibody (AB17969)

  • 0
  • 0
Primary Antibodies

AB300521

Anti-KAT5 / Tip60 antibody [EPR23728-112]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-KAT5 / Tip60 antibody [EPR23728-112] (AB300521)

  • 0
  • 0
Primary Antibodies

AB205018

Anti-GAS41 antibody

Immunoprecipitation - Anti-GAS41 antibody (AB205018)

  • 5
  • 1
Primary Antibodies

AB183663

Anti-MRG15 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MRG15 antibody (AB183663)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

L3MBTL1 also known as the MBT domain-containing protein L3MBTL1 is a protein that plays a role in chromatin remodeling. This protein has a molecular mass of approximately 83 kDa. It is expressed in various tissues including hematopoietic progenitor cells and the brain. L3MBTL1 interacts with DNA and histones participating in the modification of chromatin structure important for gene expression regulation.
Biological function summary

L3MBTL1 functions as a transcriptional repressor involved in cell cycle regulation and differentiation. It acts by binding to methylated lysines on histone tails affecting chromatin compaction and accessibility. L3MBTL1 is part of the Polycomb group (PcG) protein complex which maintains genes in a repressed state ensuring proper cell fate determination.

Pathways

L3MBTL1 is an important component in chromatin modification and transcriptional repression pathways. It participates in pathways such as the Polycomb Repressive Complex 1 (PRC1)-mediated gene silencing pathway. L3MBTL1 interacts with other Polycomb proteins such as BMI1 and RING1 to ensure effective repression of target genes.

L3MBTL1 has a strong connection to certain types of cancer and genetic syndromes. Alterations in L3MBTL1 expression or function can contribute to hematological malignancies like acute myeloid leukemia. It is also linked to developmental disorders due to its role in epigenetic regulation during development. L3MBTL1 may interact with proteins like EZH2 a related PcG protein influencing the progression of these diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes : acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
See full target information L3MBTL1

대체 명칭 보기

KIAA0681, L3MBT, L3MBTL, L3MBTL1, Lethal(3)malignant brain tumor-like protein 1, H-l(3)mbt, H-l(3)mbt protein, L(3)mbt-like, L(3)mbt protein homolog
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell death & disease 15:649 PubMed39231972

2024

L3MBTL1, a polycomb protein, promotes Osimertinib acquired resistance through epigenetic regulation of DNA damage response in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zihe Zhang,Yongwen Li,Ruifeng Shi,Chaoyi Jia,Songlin Xu,Guangsheng Zhu,Peijun Cao,Hua Huang,Xuanguang Li,Hongbing Zhang,Minghui Liu,Chen Chen,Hongyu Liu,Chunsheng Kang,Jun Chen

Nature communications 13:5493 PubMed36123338

2022

Extracellular fibrinogen-binding protein released by intracellular Staphylococcus aureus suppresses host immunity by targeting TRAF3.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaokai Zhang,Tingrong Xiong,Lin Gao,Yu Wang,Luxuan Liu,Tian Tian,Yun Shi,Jinyong Zhang,Zhuo Zhao,Dongshui Lu,Ping Luo,Weijun Zhang,Ping Cheng,Haiming Jing,Qiang Gou,Hao Zeng,Dapeng Yan,Quanming Zou
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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