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AB235089

Anti-L3MBTL4 antibody

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Rabbit Polyclonal L3MBTL4 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human L3MBTL4 aa 1-300.

대체 명칭 보기

Lethal(3)malignant brain tumor-like protein 4, H-l(3)mbt-like protein 4, L(3)mbt-like protein 4, L3mbt-like 4, L3MBTL4

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-L3MBTL4 antibody (AB235089)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-L3MBTL4 antibody (AB235089)

Paraffin-embedded human testis tissue stained for L3MBTL4 using ab235089 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-L3MBTL4 antibody (AB235089)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-L3MBTL4 antibody (AB235089)

Paraffin-embedded human prostate cancer tissue stained for L3MBTL4 using ab235089 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human L3MBTL4 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q8NA19

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보완 제품

Primary Antibodies

AB235046

Anti-WDR37 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR37 antibody (AB235046)

  • 0
  • 0
Primary Antibodies

AB237532

Anti-SPTLC3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SPTLC3 antibody (AB237532)

  • 0
  • 0
Primary Antibodies

AB234981

Anti-GNPNAT1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GNPNAT1 antibody (AB234981)

  • 0
  • 0
Primary Antibodies

AB234847

Anti-TRIM13 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIM13 antibody (AB234847)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

L3MBTL4 also known as L(3)mbt-like protein 4 belongs to the Polycomb group of proteins. It has a molecular mass of approximately 110 kDa. This protein mainly functions as a chromatin reader recognizing and binding to methylated histone tails. L3MBTL4 localizes to the nucleus where it is involved in chromatin remodeling. Expression of L3MBTL4 occurs in many tissues with higher levels seen in brain and testes suggesting a role in these areas.
Biological function summary

L3MBTL4 influences chromatin state and gene expression by interacting with other chromatin-associated proteins participating in the silencing of genes. This protein is a part of larger complexes involved in chromatin modification notably influencing transcriptional repression activities. It contributes to the regulation of various genes thereby impacting cell cycle progression and differentiation events within cells.

Pathways

L3MBTL4 participates in the regulation of key processes such as the cell cycle and epigenetic modification pathways. It interacts with proteins like RB and members of the PcG complex to modulate these pathways ensuring appropriate cell proliferation and differentiation. L3MBTL4 also plays a role in histone modification pathways further highlighting its importance in gene expression regulation through its interaction with other chromatin modulators.

L3MBTL4 has been associated with certain cancers and neurodevelopmental disorders. Dysregulation of L3MBTL4 expression or function can contribute to tumorigenesis particularly influencing pathways involving RB protein and other chromatin-related proteins. Additionally its misregulation might impact neurodevelopmental pathways potentially linking it to disorders such as intellectual disability where it may interact with proteins implicated in neuronal development.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity).
See full target information L3MBTL4
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 14:3729 PubMed37349316

2023

Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xue Jiang,Yu Cheng,Yuzhang Zhu,Caoling Xu,Qiaodan Li,Xuemei Xing,Wenqing Li,Jiaqi Zou,Lan Meng,Muhammad Azhar,Yuzhu Cao,Xianhong Tong,Weibing Qin,Xiaoli Zhu,Jianqiang Bao
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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