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AB122197

Anti-LCLAT1 antibody

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Rabbit Polyclonal LCLAT1 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LCLAT1 aa 200 to C-terminus.

대체 명칭 보기

AGPAT8, ALCAT1, LYCAT, UNQ1849/PRO3579, LCLAT1, Lysocardiolipin acyltransferase 1, 1-acylglycerol-3-phosphate O-acyltransferase 8, Acyl-CoA:lysocardiolipin acyltransferase 1, 1-AGP acyltransferase 8, 1-AGPAT 8

5 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LCLAT1 antibody (AB122197)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LCLAT1 antibody (AB122197)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human heart muscle tissue labelling LCLAT1 with ab122197 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LCLAT1 antibody (AB122197)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LCLAT1 antibody (AB122197)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human duodenum tissue labelling LCLAT1 with ab122197 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunocytochemistry - Anti-LCLAT1 antibody (AB122197)
  • ICC

Unknown

Immunocytochemistry - Anti-LCLAT1 antibody (AB122197)

Immunocytochemistry/immunofluorescence analysis of human cell line A-431 shows labelling LCLAT1 with ab122197 at 2 μg/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LCLAT1 antibody (AB122197)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LCLAT1 antibody (AB122197)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fallopian tube tissue labelling LCLAT1 with ab122197 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LCLAT1 antibody (AB122197)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LCLAT1 antibody (AB122197)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling LCLAT1 with ab122197 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LCLAT1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6UWP7

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대체품

Primary Antibodies

AB153987

Anti-LCLAT1 antibody

Western blot - Anti-LCLAT1 antibody (AB153987)

  • 0
  • 0

보완 제품

Primary Antibodies

AB223726

Anti-PNPLA8 antibody

Immunocytochemistry/ Immunofluorescence - Anti-PNPLA8 antibody (AB223726)

  • 0
  • 0
Primary Antibodies

AB237612

Anti-PLD6 antibody

Immunocytochemistry/ Immunofluorescence - Anti-PLD6 antibody (AB237612)

  • 0
  • 0
Primary Antibodies

AB178846

Anti-Iba1 antibody [EPR16588] - Microglia marker

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Iba1 antibody [EPR16588] - Microglia marker (AB178846)

  • 5
  • 50
Primary Antibodies

AB307148

Anti-Tafazzin/TAZ antibody [EPR26956-58]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-Tafazzin/TAZ antibody [EPR26956-58] (AB307148)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Lysocardiolipin acyltransferase 1 (LCLAT1) also known as monolysocardiolipin acyltransferase (MLCL AT-1) is an enzyme with a mass of approximately 58 kDa. LCLAT1 resides primarily in the mitochondria and plays a significant role in phospholipid metabolism by catalyzing the reacylation of monolysocardiolipin (MLCL) to cardiolipin (CL). This function is critical for maintaining mitochondrial membrane structure and function. Expression of LCLAT1 occurs in various tissues with notable presence in heart and skeletal muscle where high energy demand correlates with mitochondrial activity.
Biological function summary

LCLAT1 functions within the lipid remodeling pathway specific to the mitochondria and is an important player in the maintenance of mitochondrial function and energy metabolism. This enzyme acts independently not as part of a larger protein complex. LCLAT1 ensures the proper composition of cardiolipin which is essential for the optimal performance of respiratory chain complexes and cellular energy homeostasis.

Pathways

The enzyme LCLAT1 plays a vital role in lipid metabolism particularly the remodeling pathway of cardiolipin in mitochondria. This pathway is vital for the functionality of the electron transport chain an important element in cellular respiration. LCLAT1 interconnects with Tafazzin (TAZ) another enzyme critical in cardiolipin biosynthesis and remodeling highlighting its participation in maintaining mitochondrial health and efficient aerobic energy supply.

Alterations in LCLAT1 function have connections to mitochondrial diseases due to its role in cardiolipin remodeling. Disruptions in its activity may relate to Barth syndrome a genetic disorder linked to defects in cardiolipin metabolism. LCLAT1's association with Tafazzin (TAZ) further implicates it in the disorder as both proteins are essential for proper cardiolipin function and mitochondrial integrity.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Exhibits acyl-CoA : lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed : 16620771). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (PubMed : 19075029). Required for establishment of the hematopoietic and endothelial lineages (By similarity).
See full target information LCLAT1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of translational medicine 23:902 PubMed40804742

2025

Cancer cell SPOCD1 promotes colorectal cancer liver metastasis by activating the CXCL12/CXCR4 signaling pathway in cancer-associated fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Geng Peng,Lin Zhong,Lina Luo,Yongle Ju,Yan Lu,Lui Ng,Dominic Chi-Chung Foo,Fu Cheng,Luji Huang,Manzhao Ouyang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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