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AB231146

Anti-LCN12 antibody

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Rabbit Polyclonal LCN12 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LCN12 aa 50 to C-terminus.

대체 명칭 보기

Epididymal-specific lipocalin-12, LCN12

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LCN12 antibody (AB231146)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LCN12 antibody (AB231146)

Formalin-fixed, paraffin-embedded human kidney tissue stained for LCN12 with ab231146 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-LCN12 antibody (AB231146)
  • WB

Supplier Data

Western blot - Anti-LCN12 antibody (AB231146)

All lanes:

Western blot - Anti-LCN12 antibody (ab231146) at 3 µg/mL

All lanes:

Mouse testis lysate

Secondary

All lanes:

HRP-Linked Guinea pig anti-Rabbit at 1/1000 dilution

Predicted band size: 22 kDa

false

Western blot - Anti-LCN12 antibody (AB231146)
  • WB

Supplier Data

Western blot - Anti-LCN12 antibody (AB231146)

All lanes:

Western blot - Anti-LCN12 antibody (ab231146) at 2 µg/mL

All lanes:

Recombinant human LCN12 protein

Predicted band size: 22 kDa,68 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human LCN12 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6JVE5

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보완 제품

Primary Antibodies

AB62050

Anti-Prostaglandin E Synthase/MPGES-1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Synthase/MPGES-1 antibody (AB62050)

  • 5
  • 3
Primary Antibodies

AB215752

Anti-Profilin 1 (phospho S138) antibody

Lab Essentials

Western blot - Anti-Profilin 1 (phospho S138) antibody (AB215752)

  • 0
  • 0
Primary Antibodies

AB110056

Anti-JP-2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JP-2 antibody (AB110056)

  • 1
  • 1
Primary Antibodies

AB124904

Anti-Profilin 1 antibody [EPR6304]

KO Validated|RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Profilin 1 antibody [EPR6304] (AB124904)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab231146 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

LCN12 also known as Lipocalin 12 is a protein belonging to the lipocalin family characterized by their ability to bind and transport small hydrophobic molecules. LCN12 shows a molecular mass of approximately 23 kDa. Researchers observe LCN12 expression in various tissues with notable presence in adipose tissue and skeletal muscles. Unlike some other lipocalins specific binding partners and detailed mechanical functions of LCN12 are lesser-known but it involves the transport of certain molecules that are yet to be fully identified.
Biological function summary

Within cellular environments LCN12 plays a role in lipid metabolism affecting processes involving fatty acids and cholesterol. It does not appear as part of large protein complexes like some other lipocalins. Instead LCN12 often acts independently to influence lipid transportation and storage which impacts cellular energy homeostasis and metabolic regulation. Its precise molecular partners remain under investigation but studies suggest potential interactions with other lipid-related proteins.

Pathways

LCN12 interacts with metabolic pathways especially those related to lipid regulation and energy homeostasis. The protein is linked to the lipid metabolic pathway where it may interact with enzymes and transporters that modify or relocate lipid molecules. Another pathway integrating LCN12 is the insulin signaling pathway where it connects to proteins like adiponectin and leptin which are critical to maintaining proper metabolic functions and energy balance in the body.

LCN12 displays potential connections to metabolic disorders such as obesity and type 2 diabetes. Researchers suggest that abnormal LCN12 expression or function may contribute to the imbalance of lipid metabolism influencing the development of these conditions. In the context of obesity LCN12 is associated with the protein leptin which regulates appetite and fat storage indicating a broader role in energy regulation and metabolic diseases. Understanding this link between LCN12 and metabolic disorders may offer insightful targets for therapeutic interventions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity).
See full target information LCN12
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular medicine reports 23: PubMed33760220

2021

MST1 inhibits the progression of breast cancer by regulating the Hippo signaling pathway and may serve as a prognostic biomarker.

Applications

Unspecified application

Species

Unspecified reactive species

Xiang Jin,Lihua Zhu,Sheng Xiao,Zhuhong Cui,Jing Tang,Jiangyong Yu,Mingjun Xie
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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