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AB316956

Anti-LCOR antibody

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Rabbit Polyclonal LCOR antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LCOR.

대체 명칭 보기

C10orf12, KIAA1795, MLR2, LCOR, Ligand-dependent corepressor, LCoR, Mblk1-related protein 2

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human LCOR.

Q96JN0

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보완 제품

Primary Antibodies

AB300615

Anti-Nuclear Receptor Corepressor NCoR antibody [EPR23834-46]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-Nuclear Receptor Corepressor NCoR antibody [EPR23834-46] (AB300615)

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  • 0
Primary Antibodies

AB264188

Anti-NCOR2/SMRT antibody

Immunoprecipitation - Anti-NCOR2/SMRT antibody (AB264188)

  • 0
  • 0
Primary Antibodies

AB319110

Anti-TCF-3/TCF7L1 antibody [EPR28832-90] - BSA and Azide free

Recombinant|RabMAb

Western blot - Anti-TCF-3/TCF7L1 antibody [EPR28832-90] - BSA and Azide free (AB319110)

  • 0
  • 0
Primary Antibodies

AB109313

Anti-TBX1 antibody [EPR3289(2)]

RabMAb|Recombinant

Western blot - Anti-TBX1 antibody [EPR3289(2)] (AB109313)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C|-80°C
적절한 장기 보관 조건
-20°C|-80°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

LCOR or Ligand-dependent Corepressor serves as a transcriptional corepressor protein playing an integral mechanical role in regulating gene expression. It weighs approximately 66 kDa. Scientists have identified LCOR expression in various tissues including breast lung and liver. The protein interacts with nuclear receptors and transcription factors modulating their activity by silencing gene transcription. Its activity relies on binding to ligand-activated receptors.
Biological function summary

LCOR contributes to the regulation of transcription and modulation of hormone signaling pathways. It operates as a part of a larger multi-protein complex working with other corepressors like NCoR (Nuclear receptor Corepressor) and SMRT (Silencing Mediator of Retinoic acid and Thyroid hormone receptor). This collaboration results in refined control over gene expression particularly in pathways influenced by estrogen and retinoic acid influencing cellular functions such as proliferation and differentiation.

Pathways

LCOR plays a role in significant signaling pathways like estrogen receptor signaling and retinoid metabolism. In these pathways LCOR interacts with proteins such as ERα (Estrogen Receptor alpha) and RXR (Retinoid X Receptor) respectively facilitating the repression of target genes involved in diverse physiological processes. These interactions help modulate cellular responses to hormonal changes further affecting gene transcription profiles.

LCOR is involved in breast cancer and other hormone-dependent malignancies. In breast cancer researchers have found altered LCOR expression linked to disease progression often associated with altered ERα activity. Additionally its interaction with other corepressors like NCoR and SMRT suggests a broader impact on transcriptional dysregulation in these diseases. Understanding LCOR's regulatory role offers potential insights for targeted therapeutic strategies in treating these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.
See full target information LCOR
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Product promise

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