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AB235340

Anti-LDAH antibody

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Rabbit Polyclonal LDAH antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LDAH.

대체 명칭 보기

C2orf43, LDAH, Lipid droplet-associated hydrolase, Lipid droplet-associated serine hydrolase, hLDAH

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LDAH antibody (AB235340)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LDAH antibody (AB235340)

Paraffin-embedded human testis tissue stained for LDAH with ab235340 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LDAH antibody (AB235340)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LDAH antibody (AB235340)

Paraffin-embedded human pancreatic tissue stained for LDAH with ab235340 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LDAH antibody (AB235340)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LDAH antibody (AB235340)

Paraffin-embedded human adrenal gland tissue stained for LDAH with ab235340 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human LDAH.

Q9H6V9

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보완 제품

Primary Antibodies

AB52488

Anti-Lactate Dehydrogenase antibody [EP1566Y]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Lactate Dehydrogenase antibody [EP1566Y] (AB52488)

  • 4
  • 7
Primary Antibodies

AB231698

Anti-Lactate Dehydrogenase antibody [EP1563Y] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lactate Dehydrogenase antibody [EP1563Y] - BSA and Azide free (AB231698)

  • 0
  • 0
Primary Antibodies

AB209847

Anti-Hexokinase II antibody [EPR20839]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-Hexokinase II antibody [EPR20839] (AB209847)

  • 5
  • 2
Primary Antibodies

AB199438

Anti-PGK1 antibody [EPR19057]

RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-PGK1 antibody [EPR19057] (AB199438)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

LDAH also known as Lipid Dehydrogenase functions as an enzyme involved in lipid metabolism. Its mass is approximately 45 kDa. This protein is highly expressed in tissues with active lipid metabolism such as the liver and adipose tissue. LDAH plays a role in lipid oxidation aiding in the conversion of lipid substrates into various metabolic intermediates. The enzyme ensures efficient lipid utilization contributing to energy homeostasis within the cell.
Biological function summary

The enzyme LDAH facilitates the breakdown and conversion of lipid molecules optimizing cellular energy balance. LDAH operates as an important component within a larger enzymatic complex that includes other dehydrogenases. The interactions and activities within this complex regulate the lipid metabolic processes influencing the energy output available for cellular functions. LDAH's activity is modulated through its interaction with co-factors and substrates impacting its efficiency and metabolic outcomes.

Pathways

LDAH integrates into essential lipid metabolism pathways such as the fatty acid beta-oxidation pathway. This pathway is critical for breaking down fatty acids into acetyl-CoA a molecule pivotal in energy supply through the citric acid cycle. LDAH's function complements the roles of related proteins like Acyl-CoA dehydrogenase aiding in the removal of electrons from fatty acids during metabolic processes. These relationships position LDAH as an important player in maintaining cellular energy dynamics and responding to metabolic demands.

Altered LDAH activity connects to metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Dysregulation of LDAH can lead to impaired lipid metabolism resulting in fat accumulation and insulin resistance key characteristics of these conditions. LDAH's interaction with proteins such as Acyl-CoA dehydrogenase and regulators of mitochondrial function highlights its role in these diseases. Researchers study LDAH as a potential therapeutic target for managing lipid-related metabolic disorders seeking ways to modulate its function to restore metabolic balance.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Probable serine lipid hydrolase associated with lipid droplets (By similarity). Has low cholesterol esterase activity (By similarity). Appears to lack triglyceride lipase activity (By similarity). Involved in cholesterol and triglyceride homeostasis; has opposing effects, stimulating cellular triglyceride accumulation and cellular cholesterol release (PubMed : 24357060, PubMed : 28578400). Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores (PubMed : 28578400). May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation (PubMed : 28578400). Promotes microtubule-dependent lipid droplet fusion (PubMed : 28578400). Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages (By similarity).
See full target information LDAH
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The EMBO journal 40:e106336 PubMed33595114

2021

NHP2 downregulation counteracts hTR-mediated activation of the DNA damage response at ALT telomeres.

Applications

Unspecified application

Species

Unspecified reactive species

Maya Raghunandan,Dan Geelen,Eva Majerova,Anabelle Decottignies
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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