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AB236509

Anti-LGALS3BP antibody [OTI3D6]

3

(1 리뷰)

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(3 제품이 사용된 논문 )

Mouse Monoclonal LGALS3BP antibody. Suitable for WB, IHC-P, ICC/IF, Flow Cyt (Intra) and reacts with Human, Recombinant fragment - Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LGALS3BP aa 1-300.

대체 명칭 보기

M2BP, LGALS3BP, Galectin-3-binding protein, Basement membrane autoantigen p105, Lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, Tumor-associated antigen 90K, MAC2BP, Mac-2 BP

7 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS3BP antibody [OTI3D6] (AB236509)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS3BP antibody [OTI3D6] (AB236509)

Paraffin-embedded human lung carcinoma tissue stained for LGALS3BP using ab236509 at 1/150 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS3BP antibody [OTI3D6] (AB236509)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS3BP antibody [OTI3D6] (AB236509)

Paraffin-embedded human bladder carcinoma tissue stained for LGALS3BP using ab236509 at 1/150 dilution in immunohistochemical analysis.

Flow Cytometry (Intracellular) - Anti-LGALS3BP antibody [OTI3D6] (AB236509)
  • Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-LGALS3BP antibody [OTI3D6] (AB236509)

Flow cytometric analysis of HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) cells transfected with empty vector control (blue) or vector expressing LGALS3BP (red), labeling LGALS3BP with ab236509 at 1/100 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS3BP antibody [OTI3D6] (AB236509)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS3BP antibody [OTI3D6] (AB236509)

Paraffin-embedded human prostate tissue stained for LGALS3BP using ab236509 at 1/150 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS3BP antibody [OTI3D6] (AB236509)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS3BP antibody [OTI3D6] (AB236509)

Paraffin-embedded human endometrium adenocarcinoma tissue stained for LGALS3BP using ab236509 at 1/150 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-LGALS3BP antibody [OTI3D6] (AB236509)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-LGALS3BP antibody [OTI3D6] (AB236509)

COS-7 (African green monkey kidney fibroblast-like cell line) cells transfected with pCMV6-ENTRY LGALS3BP cDNA stained for LGALS3BP (green) using ab236509 at 1/100 dilution in ICC/IF.

Western blot - Anti-LGALS3BP antibody [OTI3D6] (AB236509)
  • WB

Unknown

Western blot - Anti-LGALS3BP antibody [OTI3D6] (AB236509)

All lanes:

Western blot - Anti-LGALS3BP antibody [OTI3D6] (ab236509) at 1/500 dilution

Lane 1:

HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) transfected with pCMV6-ENTRY control cDNA, whole cell lysate at 5 µg

Lane 2:

HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) transfected with pCMV6-ENTRY LGALS3BP cDNA, whole cell lysate at 5 µg

Predicted band size: 65 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI3D6

Isotype

IgG2a

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, Flow Cyt (Intra), IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LGALS3BP aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q08380

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대체품

Primary Antibodies

AB67353

Anti-LGALS3BP antibody

  • 3
  • 2
Primary Antibodies

AB237031

Anti-LGALS3BP antibody [EPR21757-33] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-LGALS3BP antibody [EPR21757-33] - BSA and Azide free (AB237031)

  • 0
  • 0
Primary Antibodies

AB217760

Anti-LGALS3BP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS3BP antibody (AB217760)

  • 0
  • 0
Primary Antibodies

AB217572

Anti-LGALS3BP antibody [EPR21757-33]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-LGALS3BP antibody [EPR21757-33] (AB217572)

  • 0
  • 0

보완 제품

Assay Kits

AB213784

Human Galectin-3BP ELISA Kit

Sandwich ELISA - Human Galectin-3BP ELISA Kit (AB213784)

  • 0
  • 0
Primary Antibodies

AB179471

Anti-Integrin beta 1 antibody [EPR16895]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Integrin beta 1 antibody [EPR16895] (AB179471)

  • 5
  • 5
Primary Antibodies

AB244318

Anti-MGAT5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MGAT5 antibody (AB244318)

  • 5
  • 3
Primary Antibodies

AB209344

Anti-Galectin 3 antibody [EPR19244]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Galectin 3 antibody [EPR19244] (AB209344)

  • 5
  • 4
Primary Antibodies

AB121411

Anti-FUT11 antibody

Immunocytochemistry/ Immunofluorescence - Anti-FUT11 antibody (AB121411)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p>Heat induced epitope retrieval by 10mM citric buffer, pH 6.0, 100°C for 10 minutes.</p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/100", "FlowCytIntra-species-notes": "<p></p>" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Recombinant fragment - Human": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100", "ICCIF-species-notes": "<p></p>", "FlowCytIntra-species-checked": "notRecommended", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" } } }
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제품 세부 정보

Clone OTI3D6 (formerly 3D6).
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from cell culture supernatant.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

LGALS3BP also known as Galectin-3-binding protein (Mac-2 binding protein 90K) is a multifaceted glycoprotein with a mass of approximately 90 kDa. It typically interacts with galectins especially galectin-3 and is known for its adhesive properties. Researchers frequently observe it in various tissues including epithelial cells immune cells and in the extracellular matrix highlighting its involvement across different biological functions.
Biological function summary

The LGALS3BP glycoprotein modulates cell-cell and cell-matrix interactions. It does not operate alone; researchers have identified its presence in multiple complexes impacting several cellular processes such as immune modulation cell adhesion and migration. LGALS3BP can affect the immune response by influencing T-cell and natural killer cell activities which can alter the body's defense against pathogens and tumors.

Pathways

LGALS3BP significantly influences the signaling pathways involved with immune function and cellular adhesion. It plays an important role in the galectin pathway where it interacts with galectin-3 contributing to processes like cell growth and apoptosis. Additionally it affects the integrin-mediated signaling pathway enhancing cell adhesion and motility which is vital for cell migration and signaling dynamics. These interactions involve proteins such as integrins and other adhesion molecules that influence cellular communication and structural integrity.

LGALS3BP is strongly linked to cancer and inflammation-related conditions. Its overexpression is correlated with tumor progression and metastasis as seen in various cancers such as breast and colorectal cancer. LGALS3BP modulates its effects by interacting with galectin-3 influencing tumor-immune escape mechanisms and promoting tumor growth. Further its role in inflammatory disorders suggests it contributes to pathological processes through interactions with proteins that mediate inflammation and immune response.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
See full target information LGALS3BP
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Arthritis research & therapy 26:222 PubMed39702240

2024

KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus.

Applications

Unspecified application

Species

Unspecified reactive species

Hongshuai Zhao,Zaichuan Lin,Peiwen Zhang,Jiayue Rao,Shumin Xu,Qing Luo,Junming Li

eLife 12: PubMed37010266

2023

Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Li,Xinqi Lou,Yingjie Zha,Yinyin Qin,Jun Zha,Lei Hong,Zhanli Xie,Shudi Yang,Chen Wang,Jianzhong An,Zhenhao Zhang,Shigang Qiao

Investigative ophthalmology & visual science 63:25 PubMed35895036

2022

LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia.

Applications

Unspecified application

Species

Unspecified reactive species

Chenyang Zhao,Yusen Liu,Jiayu Meng,Xiaotang Wang,Xianyang Liu,Wanqian Li,Qian Zhou,Junjie Xiang,Na Li,Shengping Hou
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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