Rabbit Polyclonal LILRA3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LILRA3 aa 200-350.
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CD85e, ILT6, LIR4, LILRA3, Leukocyte immunoglobulin-like receptor subfamily A member 3, CD85 antigen-like family member E, Immunoglobulin-like transcript 6, Leukocyte immunoglobulin-like receptor 4, Monocyte inhibitory receptor HM43/HM31, ILT-6, LIR-4
- IHC-P
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LILRA3 antibody (AB235108)
Paraffin-embedded human lung tissue stained for LILRA3 using ab235108 at 1/300 dilution in immunohistochemical analysis.
After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at room temperature. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized tissue using an HRP conjugated SP system.
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
LILRA3 modulates immune responses by binding to unknown ligands. It does not associate with any known receptor complex because it does not possess a transmembrane or cytoplasmic domain. LILRA3 may act as a natural antagonist to other LILR receptors by interfering with their ligand interactions. This antagonism helps regulate the functions of the innate and adaptive immune responses by competing with membrane-bound LILR forms for binding with common ligands.
Pathways
LILRA3 influences the pathways involved in immune regulation including the modulation of cytokine production. It has been linked to pathways associated with the inhibition of inflammation intersecting with receptors like LILRA2 and LILRB1 which are also part of the LILR family. These interactions are essential in balancing immune responses possibly by inhibiting excessive activation that could lead to inflammation or autoimmunity.
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제품이 사용된 논문 (1)
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Molecular biology of the cell 35:ar133 PubMed39196658
2024
Applications
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Species
Unspecified reactive species
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