AB224113

Anti-LMO7 antibody

Name: Anti-LMO7 antibody
Brand: Abcam Limited
SKU: AB224113
Rating: 5 (1 reviews)

(1 리뷰)

(4 제품이 사용된 논문 )

Rabbit Polyclonal LMO7 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LMO7 aa 650 to C-terminus.

대체 명칭 보기

FBX20, FBXO20, KIAA0858, LMO7, LIM domain only protein 7, LMO-7, F-box only protein 20, LOMP

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMO7 antibody (AB224113)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMO7 antibody (AB224113)

Paraffin-embedded human skeletal muscle tissue stained for LMO7 using ab224113 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMO7 antibody (AB224113)

Paraffin-embedded human testis tissue stained for LMO7 using ab224113 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMO7 antibody (AB224113)

Paraffin-embedded human uterine cervix tissue stained for LMO7 using ab224113 at 1/200 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-LMO7 antibody (AB224113)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-LMO7 antibody (AB224113)

PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for LMO7 (green) using ab224113 at 4 μg/ml in ICC/IF.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMO7 antibody (AB224113)

Paraffin-embedded human duodenum tissue stained for LMO7 using ab224113 at 1/200 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LMO7 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8WWI1

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "Fixation/Permeabilization: PFA/Triton X-100." } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

LMO7 known also as LIM-only protein 7 plays a significant mechanical role in cellular architecture and gene expression. This protein with a molecular mass of approximately 165 kDa not only localizes to the nuclear envelope but also to the cytoplasm. It is found in many tissues with higher expression levels noted in skeletal muscle and heart tissue. LMO7 contains LIM domains that facilitate protein-protein interactions important for its varied functions within the cell.

Biological function summary

LMO7 supports cellular integrity and function through its roles at the nuclear periphery. It interacts with nuclear and cytoskeletal elements contributing to processes such as nuclear shaping and stability. LMO7 participates in the assembly of the mechanotransduction complex at the nuclear membrane. This role links external mechanical signals to gene expression regulation involving other proteins in the complex and helping cells respond to mechanical stress.

Pathways

This protein integrates into the mechanotransduction pathway and the actin cytoskeleton signaling. It interacts with cellular components such as emerin and nesprin impacting cytoskeletal dynamics and nuclear positioning. In doing so LMO7 influences signal transduction pathways that affect cell migration and structural maintenance which represent important physiological functions.

LMO7 associations appear in certain muscular dystrophies and cancer. Its interaction with proteins like emerin suggests implications in Emery-Dreifuss muscular dystrophy a condition characterized by weakened skeletal muscles. Additionally altered LMO7 expression or function has connections to certain cancers where it may affect tumor suppressor pathways and metastatic potential linking it indirectly to aberrations in cell adhesion and motility.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information LMO7

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

iScience 26:106600 PubMed37213233

2023

FAP promotes metastasis and chemoresistance via regulating YAP1 and macrophages in mucinous colorectal adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Dengbo Ji,Jinying Jia,Xinxin Cui,Zhaowei Li,Aiwen Wu

Stem cells international 2023:2826815 PubMed37964983

2023

A Novel Molecular Classification Method for Glioblastoma Based on Tumor Cell Differentiation Trajectories.

Applications

Unspecified application

Species

Unspecified reactive species

Guanghao Zhang,Xiaolong Xu,Luojiang Zhu,Sisi Li,Rundong Chen,Nan Lv,Zifu Li,Jing Wang,Qiang Li,Wang Zhou,Pengfei Yang,Jianmin Liu

Bone research 11:1 PubMed36588108

2023

A novel molecular classification method for osteosarcoma based on tumor cell differentiation trajectories.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Zhang,Ting Wang,Haiyi Gong,Runyi Jiang,Wang Zhou,Haitao Sun,Runzhi Huang,Yao Wang,Zhipeng Wu,Wei Xu,Zhenxi Li,Quan Huang,Xiaopan Cai,Zaijun Lin,Jinbo Hu,Qi Jia,Chen Ye,Haifeng Wei,Jianru Xiao

JOR spine 5:e1210 PubMed36601375

2022

Comparative proteome analysis of the ligamentum flavum of patients with lumbar spinal canal stenosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yutaka Yabe,Yoshihiro Hagiwara,Masahiro Tsuchiya,Takashi Minowa,Taro Takemura,Shinya Hattori,Shinichirou Yoshida,Takahiro Onoki,Keisuke Ishikawa

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-LMO7 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMO7 antibody (AB224113)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMO7 antibody (AB224113)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMO7 antibody (AB224113)

Immunocytochemistry/ Immunofluorescence - Anti-LMO7 antibody (AB224113)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMO7 antibody (AB224113)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (4)

Product promise