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AB244278

Anti-LNK antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal LNK antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SH2B3 aa 200-400.

대체 명칭 보기

LNK, SH2B3, SH2B adapter protein 3, Lymphocyte adapter protein, Lymphocyte-specific adapter protein Lnk, Signal transduction protein Lnk

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-LNK antibody (AB244278)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-LNK antibody (AB244278)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for LNK (green) using ab244278 at 4 μg/ml in ICC/IF.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SH2B3 aa 200-400. The exact immunogen used to generate this antibody is proprietary information.

Q9UQQ2

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대체품

Primary Antibodies

AB191904

Anti-LNK antibody

Western blot - Anti-LNK antibody (AB191904)

  • 0
  • 0
Primary Antibodies

AB128222

Anti-LNK antibody

  • 0
  • 0
Primary Antibodies

AB154848

Anti-LNK antibody [EPR7342]

RabMAb|Recombinant

Western blot - Anti-LNK antibody [EPR7342] (AB154848)

  • 4
  • 1

보완 제품

Primary Antibodies

AB32101

Anti-JAK2 (phospho Y1007 + Y1008) + JAK1 (phospho Y1034 + Y1035) antibody [E132]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-JAK2 (phospho Y1007 + Y1008) + JAK1 (phospho Y1034 + Y1035) antibody [E132] (AB32101)

  • 3
  • 4
Primary Antibodies

AB111912

Anti-Somatostatin 28 antibody [EPR3359(2)]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Somatostatin 28 antibody [EPR3359(2)] (AB111912)

  • 5
  • 4
Primary Antibodies

AB64965

Anti-TRAP220/MED1 antibody

Western blot - Anti-TRAP220/MED1 antibody (AB64965)

  • 5
  • 6
Primary Antibodies

AB243660

Anti-Carbonic Anhydrase 9/CA9 antibody [EPR23055-5]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Carbonic Anhydrase 9/CA9 antibody [EPR23055-5] (AB243660)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

LNK also known as SH2B3 is an adaptor protein about 70 kDa in mass. LNK contains an SH2 domain and is expressed mainly in hematopoietic cells including stem and progenitor cells. This protein inhibits signaling pathways by binding with receptors and blocking further transduction. It works by negatively regulating signals mediated by cytokine receptors and receptor tyrosine kinases.
Biological function summary

The LNK protein functions as a negative regulator in the hematopoietic system helping to control cell proliferation and immune response. LNK interacts with other signaling proteins as part of regulatory complexes often utilizing its SH2 domain to bind phosphorylated tyrosines. By doing so it inhibits the activity of various kinases involved in cell division ensuring proper signaling and growth control. This role is important to maintaining cellular homeostasis and preventing excessive cell proliferation.

Pathways

The LNK protein plays significant roles in the JAK-STAT and PI3K-AKT signaling pathways. In these pathways LNK interacts with signaling molecules like JAK2 and STAT5 to limit excessive signaling. This interaction is known to affect cellular responses to growth factors and cytokines impacting processes such as cell survival and proliferation. Through its activity in these pathways LNK helps ensure appropriate cellular responses to external stimuli.

LNK has connections with conditions like myeloproliferative neoplasms and hypertension. Mutations or aberrant expression of LNK can lead to dysregulated signaling that contributes to these diseases. In myeloproliferative neoplasms altered LNK function can lead to uncontrolled cell proliferation through interactions with proteins such as JAK2. In hypertension its role in regulating vascular tone and inflammation highlights its potential involvement in the pathogenesis of the disease.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
See full target information SH2B3
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell reports 43:114309 PubMed38848215

2024

Lineage specification in glioblastoma is regulated by METTL7B.

Applications

Unspecified application

Species

Unspecified reactive species

Myrianni Constantinou,James Nicholson,Xinyu Zhang,Eleni Maniati,Sara Lucchini,Gabriel Rosser,Claire Vinel,Jun Wang,Yau Mun Lim,Sebastian Brandner,Sven Nelander,Sara Badodi,Silvia Marino

Aging 12:17150-17166 PubMed32911464

2020

LNK deficiency decreases obesity-induced insulin resistance by regulating GLUT4 through the PI3K-Akt-AS160 pathway in adipose tissue.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaozhu Zhong,Chuanfeng Ke,Zhaoxi Cai,Hao Wu,Yang Ye,Xiaolin Liang,Liqun Yu,Sushi Jiang,Jun Shen,Laiyou Wang,Meiqing Xie,Guanlei Wang,Xiaomiao Zhao
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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