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AB238727

Anti-LRRC32 antibody

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Rabbit Polyclonal LRRC32 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LRRC32 aa 300-500.

대체 명칭 보기

D11S833E, LRRC32, Transforming growth factor beta activator LRRC32, Garpin, Glycoprotein A repetitions predominant, Leucine-rich repeat-containing protein 32, GARP

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRC32 antibody (AB238727)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRC32 antibody (AB238727)

Paraffin-embedded human colon cancer tissue stained for LRRC32 using ab238727 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LRRC32 aa 300-500. The exact immunogen used to generate this antibody is proprietary information.

Q14392

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대체품

Primary Antibodies

AB210264

PE Anti-LRRC32 antibody [GARP5]

Flow Cytometry - PE Anti-LRRC32 antibody [GARP5] (AB210264)

  • 0
  • 0

보완 제품

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB224703

Anti-NCR1/NKp46 antibody [EPR22403-57]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCR1/NKp46 antibody [EPR22403-57] (AB224703)

  • 5
  • 1
Primary Antibodies

AB108308

Anti-CD147 antibody [EPR4053]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD147 antibody [EPR4053] (AB108308)

  • 3
  • 1
Primary Antibodies

AB150376

Anti-LRRC15 antibody [EPR8188(2)]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-LRRC15 antibody [EPR8188(2)] (AB150376)

  • 4
  • 4
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

LRRC32 also known as GARP (Glycoprotein A Repetitions Predominant) is a membrane protein with an approximate mass of 80 kDa. Scientists observe its expression mostly on regulatory T cells (Tregs) platelets and activated B cells. As an integral membrane protein LRRC32 plays an important role in cellular processes by anchoring latent transforming growth factor-beta (TGF-β) on the cell surface which is important for its regulation and activation.
Biological function summary

LRRC32 functions as part of a larger protein complex that regulates immune responses. By controlling the availability of TGF-β LRRC32 contributes directly to maintaining immune homeostasis and tolerance. Its presence on Tregs enables these cells to modulate immune responses effectively preventing excessive immune activity which could lead to autoimmune disorders. Hence LRRC32 serves as an important component in immune regulation through its interaction with and presentation of TGF-β.

Pathways

The activity of LRRC32 aligns with critical immune signaling pathways including the TGF-β signaling pathway and the FoxP3 regulatory pathway. In the TGF-β pathway it associates with other proteins like TGF-β receptor to mediate downstream signaling that influences cell growth differentiation and immune suppression. Additionally through its indirect interaction with the FoxP3 regulatory network LRRC32 aids in stabilizing Tregs and promoting their suppressive function within the immune system which involves the lineage-specific transcription factor FoxP3.

LRRC32 is relevant in conditions such as cancer and autoimmune diseases. Its association with TGF-β and FoxP3 makes it a potential target in cancer where excessive TGF-β activity might promote tumor progression and immune evasion. Conversely inadequate function of LRRC32 or TGF-β signaling could contribute to autoimmune diseases by failing to suppress harmful immune responses effectively. Its relation to GARP and TGF-β highlights its significant role in both the initiation and progression of these diseases direct implication in disease pathology and therapeutic targeting.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed : 19651619, PubMed : 19750484, PubMed : 22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed : 22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed : 22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed : 19651619, PubMed : 19750484). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).
See full target information LRRC32
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of experimental & clinical cancer research : CR 43:208 PubMed39061061

2024

SLC14A1 and TGF-β signaling: a feedback loop driving EMT and colorectal cancer metachronous liver metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Yixun Zhang,Yumeng Yang,Xuan Qi,Peng Cui,Yi Kang,Haiyi Liu,Zhigang Wei,Haibo Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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