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AB133372

Anti-LRRN4 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal LRRN4 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human LRRN4.

대체 명칭 보기

C20orf75, LRRN4, Leucine-rich repeat neuronal protein 4, Neuronal leucine-rich repeat protein 4, NLRR-4

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRN4 antibody (AB133372)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRN4 antibody (AB133372)

ab133372, at 2.5 µg/ml, staining LRRN4 in Formalin-fixed, Paraffin-embedded Human small pancreas by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRN4 antibody (AB133372)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRRN4 antibody (AB133372)

ab133372, at 2.5 µg/ml, staining LRRN4 in Formalin-fixed, Paraffin-embedded Human small intestine tissue by Immunohistochemistry.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human LRRN4. The exact immunogen used to generate this antibody is proprietary information.

Q8WUT4

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins.

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보완 제품

Primary Antibodies

AB237778

Anti-Uroplakin IIIB antibody [C362]

BOND RX™ Validated|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uroplakin IIIB antibody [C362] (AB237778)

  • 0
  • 0
Primary Antibodies

AB92548

Anti-Clusterin antibody [EPR2911]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Clusterin antibody [EPR2911] (AB92548)

  • 4
  • 3
Primary Antibodies

AB121572

Anti-SLC38A6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC38A6 antibody (AB121572)

  • 0
  • 0
Primary Antibodies

AB236546

Anti-Mesothelin antibody [MSLN/2131]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mesothelin antibody [MSLN/2131] (AB236546)

  • 3
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2.5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

LRRN4 also known as Leucine Rich Repeat Neuronal 4 represents a significant protein with a known mass of approximately 90 kDa. This protein shows expression mainly in the central nervous system where it engages in essential mechanical roles. LRRN4 is characterized by its structure which contains leucine-rich repeat domains contributing to its function in cell adhesion and signaling processes. These domains facilitate interactions with other molecules at the cellular level.
Biological function summary

The protein LRRN4 contributes to neurodevelopment and the maintenance of neuronal connections. It often works as part of a protein complex interacting with other proteins to regulate synaptic stability and neural network formation. LRRN4 helps modulate neural activity by influencing the arrangement of synapses ensuring effective communication between neurons throughout development and into adulthood.

Pathways

Research highlights LRRN4's role in neural signaling and plasticity pathways. It plays a part in neurotrophin signaling interacting with proteins such as brain-derived neurotrophic factor (BDNF) which supports neuronal survival and differentiation. Through these pathways LRRN4's functions are linked to processes like synaptic transmission and memory formation interacting with key pathway proteins that determine synaptic strength and plasticity.

LRRN4 associates with neurological disorders like autism spectrum disorders and schizophrenia. Abnormal expression or mutations in LRRN4 can disrupt neural connectivity implying its potential role in these conditions. Additionally proteins like neuroligin and neurexin which also affect synaptic connectivity and are connected to LRRN4 play contributory roles in these disorders emphasizing the importance of maintaining normal LRRN4 function for cognitive and neural health.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May play an important role in hippocampus-dependent long-lasting memory.
See full target information LRRN4
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Aging 14:9317-9337 PubMed36446386

2022

High SURF4 expression is associated with poor prognosis of breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jingtong Zhai,Jiashu Han,Cong Li,Fengzhu Guo,Fei Ma,Binghe Xu

Cancer cell international 22:158 PubMed35440048

2022

Prognostic value and biological function of LRRN4 in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Xu,Yulin Chen,Feiwu Long,Junman Ye,Xue Li,Qiaorong Huang,Dejiao Yao,Xiaoli Wang,Jin Zhao,Wentong Meng,Xianming Mo,Ran Lu,Chuanwen Fan,Tao Zhang

Genetics and molecular biology 45:e20210138 PubMed34919118

2021

The expression of LRRN4 was correlated with the progression and prognosis of colon adenocarcinoma (COAD) patients.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxian Zhang,Jianlan Xie,Diangang Liu,Shengtao Zhu,Shutian Zhang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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