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AB236744

Anti-LSM4 antibody

4

(1 리뷰)

|

(1 출판물)

Rabbit Polyclonal LSM4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LSM4.

대체 명칭 보기

U6 snRNA-associated Sm-like protein LSm4, Glycine-rich protein, GRP, LSM4

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-LSM4 antibody (AB236744)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-LSM4 antibody (AB236744)

MCF7 (Human breast adenocarcinoma cell line) cells stained for LSM4 (green) using ab236744 at 1/100 dilution in ICC/IF. Secondary antibody is an Alexa-Fluor® 488-conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSM4 antibody (AB236744)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSM4 antibody (AB236744)

Paraffin-embedded human adrenal gland tissue stained for LSM4 using ab236744 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human LSM4.

Q9Y4Z0

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대체품

Primary Antibodies

AB153959

Anti-LSM4 antibody

Immunocytochemistry/ Immunofluorescence - Anti-LSM4 antibody (AB153959)

  • 0
  • 0

보완 제품

Primary Antibodies

AB254733

Anti-SFRS11 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS11 antibody (AB254733)

  • 0
  • 0
Primary Antibodies

AB207303

Anti-alpha 1 Antitrypsin antibody [EPR17087-50]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha 1 Antitrypsin antibody [EPR17087-50] (AB207303)

  • 4
  • 2
Assay Kits

AB113851

DCFDA / H2DCFDA - Cellular ROS Assay Kit

Functional Studies (Act) - DCFDA / H2DCFDA - Cellular ROS Assay Kit (AB113851)

  • 5
  • 11
Primary Antibodies

AB45139

Anti-Vitronectin/S-Protein antibody [EP873Y]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Vitronectin/S-Protein antibody [EP873Y] (AB45139)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

LSM4 also known as Like-Sm protein 4 is a component of the LSM protein family with a molecular mass of approximately 12 kDa. It plays a mechanical role in the formation of the LSM complex which is similar to the Sm proteins involved in RNA processing. Expression of LSM4 occurs in various tissues including the brain and immune cells indicating its diverse functional significance across different biological systems.
Biological function summary

Like-Sm protein 4 plays an important role in RNA processing particularly in mRNA splicing and degradation. It forms part of the LSm1-7 complex which associates with the U6 snRNA to regulate the splicing mechanisms necessary for proper gene expression. By ensuring accurate mRNA splicing LSM4 contributes to the maintenance of cellular function and homeostasis.

Pathways

LSM4's involvement in RNA splicing positions it within the spliceosome pathway essential for processing pre-mRNA into mature mRNA. Through this pathway it collaborates with other LSm proteins and the DEAD-box helicase DDX41. LSM4 also has a role in the RNA decay pathway where it interacts with the XRN1 protein facilitating the turnover of mRNA to control gene expression levels in cells.

Errors in LSM4 function may lead to neurological disorders such as spinal muscular atrophy. This association occurs through its interaction with the SMN protein where disruptions in RNA splicing affect motor neuron survival. LSM4 also associates with cancerous conditions as improper mRNA processing can lead to oncogene activation influencing processes like cell proliferation and apoptosis.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed : 28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed : 10523320).
See full target information LSM4
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in immunology 15:1420847 PubMed38975339

2024

Integrating single-cell and spatial transcriptomic analysis to unveil heterogeneity in high-grade serous ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Haixia Luo,Kunyu Wang,Bin Li
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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