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AB238875

Anti-LY6H antibody

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Rabbit Polyclonal LY6H antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LY6H aa 1-150.

대체 명칭 보기

Lymphocyte antigen 6H, Ly-6H, LY6H

3 이미지
Immunocytochemistry/ Immunofluorescence - Anti-LY6H antibody (AB238875)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-LY6H antibody (AB238875)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for LY6H using ab238875 at a dilution of 1/100 in ICC/IF. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LY6H antibody (AB238875)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LY6H antibody (AB238875)

Paraffin-embedded human testis tissue stained for LY6H with ab238875 at a 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LY6H antibody (AB238875)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LY6H antibody (AB238875)

Paraffin-embedded human tonsil tissue stained for LY6H with ab238875 at a 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LY6H aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

O94772

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The LY6H protein also known as lymphocyte antigen 6 complex locus H is part of the Ly6/uPAR/alpha-neurotoxin superfamily. It has a mass of approximately 14 kDa. Research has shown that LY6H localizes mainly in the membrane of human neurons. It can be found in the brain and spinal cord emphasizing its importance in nervous tissue. LY6H undergoes glycosylation which seems essential for its stability or function.
Biological function summary

LY6H contributes significantly to neural processes. It acts as a modulator of neuronal signaling and synaptic plasticity important for learning and memory. This protein does not function as an individual unit; instead it forms part of a complex network with other proteins to influence neurotransmission. Understanding its role in these processes can provide insights into neural development and function.

Pathways

LY6H integrates into the neurotrophin signaling pathway and the CREB signaling pathway. These pathways are critical for cell survival development and differentiation in the nervous system. It interacts with proteins like NTRK receptors and BDNF highlighting its role in facilitating proper neural function and response to environmental stimuli.

LY6H has links to neurological diseases including Alzheimer’s disease and schizophrenia. Alterations in LY6H expression or function could potentially disrupt normal neural processes contributing to these conditions. It connects to proteins such as amyloid-beta in Alzheimer’s disease and DISC1 in schizophrenia which may help illuminate the pathology and provide potential therapeutic targets.

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

타겟 정보

Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3 : beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons.
See full target information LY6H

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

iScience 25:105358 PubMed36339256

2022

Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non-small-cell lung carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Hyoung-Oh Jeong,Hayoon Lee,Hyemin Kim,Jinho Jang,Seunghoon Kim,Taejoo Hwang,David Whee-Young Choi,Hong Sook Kim,Naeun Lee,Yoo Mi Lee,Sehhoon Park,Hyun Ae Jung,Jong-Mu Sun,Jin Seok Ahn,Myung-Ju Ahn,Keunchil Park,Semin Lee,Se-Hoon Lee
제품이 사용된 논문 모두 보기

Product promise

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