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AB243533

Anti-LYG2 antibody

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Rabbit Polyclonal LYG2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LYG2 aa 1-100.

대체 명칭 보기

LYGH, LYG2, Lysozyme g-like protein 2

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYG2 antibody (AB243533)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LYG2 antibody (AB243533)

Formalin-fixed, paraffin-embedded human brest tissue stained for LYG2 with ab243533 at 1/200 dilution in immunohistochemical analysis.

Western blot - Anti-LYG2 antibody (AB243533)
  • WB

Supplier Data

Western blot - Anti-LYG2 antibody (AB243533)

All lanes:

Western blot - Anti-LYG2 antibody (ab243533) at 0.4 µg/mL

Lane 1:

Vector only transfected HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) lysate

Lane 2:

LYG2 overexpression HEK-293T lysate

Predicted band size: 23 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human LYG2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q86SG7

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보완 제품

Proteins & Peptides

AB134601

Recombinant Human LYG2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human LYG2 protein (His tag N-Terminus) (AB134601)

  • 0
  • 0
Primary Antibodies

AB122427

Anti-NRAP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NRAP antibody (AB122427)

  • 4
  • 1
Primary Antibodies

AB250730

Anti-PHYHD1 antibody [EPR13313(B)] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-PHYHD1 antibody [EPR13313(B)] - BSA and Azide free (AB250730)

  • 0
  • 0
Primary Antibodies

AB213721

Anti-KMT2D / MLL2 antibody [EPR20604-73]

RabMAb|Recombinant|20ul selling size|Advanced Validation

Western blot - Anti-KMT2D / MLL2 antibody [EPR20604-73] (AB213721)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

LYG2 also known as Lysosomal Glycoprotein 2 is a protein with a mass of approximately 55 kDa. It plays a mechanical role in the degradation of glycoproteins within the lysosome. Expressed mainly in the kidney liver and spleen LYG2 functions as an important component of the lysosomal membrane helping to regulate the cellular process of autophagy and degradation of complex molecules. Its alternate name GP50 refers to its glycosylated nature which is important for its stability and interaction with other molecules in the lysosome.
Biological function summary

LYG2 interacts with lysosomal hydrolases to facilitate the breakdown of glycoproteins impacting cellular metabolism and waste processing. It acts as part of a multi-protein complex within the lysosome which is essential for maintaining intracellular homeostasis. By contributing to the lysosomal function LYG2 supports efficient recycling of cellular components and influences processes linked to cellular growth and energy supply.

Pathways

LYG2 participates in lysosomal degradation pathways which are integral to autophagy and the recycling of cellular materials. These pathways intersect with the endocytic pathway sharing roles with proteins such as LAMP1 and LAMP2 which are also involved in lysosomal function. LYG2's role in these pathways highlights its interconnectedness with cellular catabolic processes and its importance in maintaining cellular nutrient balance.

Dysregulation of LYG2 activity is connected to metabolic and lysosomal storage disorders. Alterations in LYG2 expression or function are linked with conditions like mucolipidosis where lysosomal storage is impaired. In such disorders LYG2 often interacts with proteins like NPC1 reflecting its role in the proper trafficking and degradation of glycoproteins within cells. Understanding LYG2's role in these diseases can help guide therapeutic strategies aimed at correcting lysosomal dysfunction.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May act as a potent antibacterial protein that may play a role in the innate immunity.
See full target information LYG2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Theranostics 10:8633-8647 PubMed32754268

2020

Identification of a Tumor Microenvironment-relevant Gene set-based Prognostic Signature and Related Therapy Targets in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Wang-Yu Cai,Zi-Nan Dong,Xiao-Teng Fu,Ling-Yun Lin,Lin Wang,Guo-Dong Ye,Qi-Cong Luo,Yu-Chao Chen
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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