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AB118121

Anti-LYST antibody [3H1]

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(1 출판물)

Mouse Monoclonal LYST antibody. Carrier free. Suitable for sELISA and reacts with Recombinant full length protein, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LYST aa 1-150.

대체 명칭 보기

CHS, CHS1, LYST, Lysosomal-trafficking regulator, Beige homolog

1 이미지
Sandwich ELISA - Anti-LYST antibody [3H1] (AB118121)
  • sELISA

Unknown

Sandwich ELISA - Anti-LYST antibody [3H1] (AB118121)

Detection limit for recombinant tagged LYST is 0.03 ng/ml as a capture antibody.

This image was generated using the ascites version of the product.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

3H1

Isotype

IgG2b

Light chain 타입

kappa

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

Recombinant Fragment Protein within Human LYST aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q99698

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대체품

Primary Antibodies

AB220481

Anti-LYST antibody

Immunocytochemistry/ Immunofluorescence - Anti-LYST antibody (AB220481)

  • 0
  • 0

보완 제품

Assay Kits

AB275905

Human LYST ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human LYST ELISA Kit (AB275905)

  • 0
  • 0
Primary Antibodies

AB20005

Biotin Anti-Candida albicans antibody

  • 0
  • 0
Primary Antibodies

AB19903

Anti-Syntenin antibody

KO Validated

Western blot - Anti-Syntenin antibody (AB19903)

  • 4
  • 4
Primary Antibodies

AB176840

Anti-Histone H3.3 antibody [EPR17899] - ChIP Grade

20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Histone H3.3 antibody [EPR17899] - ChIP Grade (AB176840)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" }, "Recombinant full length protein": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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제품 세부 정보

This product was changed from ascites to tissue culture supernatant on 15 May 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
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특성 및 보관 정보

제형
Liquid
Purity
Tissue culture supernatant
Purification 관련 사항
Purified from TCS.
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The LYST protein also known as Lysosomal Trafficking Regulator or Beige is involved in intracellular transport processes. With an approximate molecular mass of 429 kDa it plays a role in the trafficking of lysosomal contents. Expressed in various tissues it particularly affects those with a high demand for lysosomal activity such as immune system cells. As part of its mechanical function LYST regulates the morphology of lysosomes and endosomes by facilitating fusion and movement of these vesicles.
Biological function summary

LYST directly influences the cellular degradation and recycling process. The protein does not act alone but functions as part of a larger cellular machinery that maintains lysosomal homeostasis. Its role is particularly important in immune cell function where it ensures proper lysosomal delivery and secretion especially in cytotoxic T cells and natural killer cells. These activities are important for granulocyte and lymphocyte regulation ensuring a proper response to infections and cellular stress.

Pathways

The protein LYST is integral in pathways related to vesicular transport such as the endocytic and autophagic pathways. It has a well-documented interaction with proteins such as Rab7 which is important for endosome-to-lysosome trafficking. Additionally LYST interacts with components of the cytoskeleton which further influences lysosome positioning within the cell therefore supporting its central role in cellular logistic pathways.

Mutations or functional disruptions of the LYST protein are linked to Chediak-Higashi Syndrome a rare genetic disorder characterized by immunodeficiency bleeding issues and neurological problems. This condition demonstrates a connection between LYST and the immune response as well as interactions with proteins like Perforin which are also involved in immune functions. Moreover LYST alterations might contribute to pigmentary anomalies in certain skin disorders due to its involvement in melanosome biogenesis.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed : 11984006, PubMed : 25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed : 25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed : 26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed : 27881733).
See full target information LYST
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of immunology (Baltimore, Md. : 1950) 204:3008-3018 PubMed32303555

2020

CALML6 Controls TAK1 Ubiquitination and Confers Protection against Acute Inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Chunjie Sheng,Ziyang Wang,Chen Yao,Hui-Ming Chen,Guangyan Kan,Dan Wang,Hongyuan Chen,Shuai Chen
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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