AB232686

Anti-LZP antibody

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Rabbit Polyclonal LZP antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Rat Oit3 aa 250 to C-terminus.

대체 명칭 보기

Lzp, Oit3, Oncoprotein-induced transcript 3 protein, Liver-specific zona pellucida domain-containing protein

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LZP antibody (AB232686)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LZP antibody (AB232686)

Paraffin-embedded rat spleen tissue stained for LZP using ab232686 at 10 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LZP antibody (AB232686)

Paraffin-embedded rat stomach tissue stained for LZP using ab232686 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LZP antibody (AB232686)

Paraffin-embedded rat kidney tissue stained for LZP using ab232686 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-LZP antibody (AB232686)

All lanes:

Western blot - Anti-LZP antibody (ab232686) at 2 µg/mL

Lane 1:

Mouse liver lysate

Lane 2:

Rat liver lysate

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit at 1/2000 dilution

Predicted band size: 57 kDa,60 kDa

false

Supplier Data

Western blot - Anti-LZP antibody (AB232686)

All lanes:

Western blot - Anti-LZP antibody (ab232686) at 2 µg/mL

All lanes:

Recombinant rat LZP protein

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit at 1/2000 dilution

Predicted band size: 60 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Rat Oit3 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6V0K7

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

Purification 관련 사항

ab232686 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

보관 버퍼

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

LZP also known as leucine zipper protein is a structural protein that plays a significant role in various cellular processes. It has a molecular mass of approximately 25 kDa. LZP is expressed highly in the liver and lungs with moderate expression observed in the brain and heart. The presence of the leucine zipper motif in LZP allows it to function as a transcription factor facilitating the regulation of gene expression through dimerization and DNA binding.

Biological function summary

LZP interacts with other proteins to regulate cell proliferation and differentiation. The protein forms part of a larger complex involved in these cellular processes. Through its action in transcription regulation LZP influences the expression of genes critical for cell cycle progression and apoptosis. During normal cellular function LZP maintains a balance between cell growth and programmed cell death contributing to tissue homeostasis.

Pathways

Research identifies LZP playing a role in the MAPK/ERK signaling pathway and the NF-κB signaling pathway. These pathways are essential for transmitting signals from the cell surface to the DNA in the nucleus impacting cell survival and differentiation. LZP interacts closely with proteins such as c-Jun and p53 within these pathways suggesting its importance in signal transduction and gene transcription.

LZP has connections to certain types of cancer including liver and lung cancer. Studies indicate that aberrant expression or mutations in LZP can lead to uncontrolled cell proliferation contributing to tumorigenesis. In addition LZP's interaction with the protein p53 known for its tumor-suppressing activities highlights its role in these diseases. Understanding LZP's functions and pathways offers potential targets for therapeutic intervention in related disorders.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

May be involved in hepatocellular function and development.

See full target information Oit3

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular cancer research : MCR 21:975-990 PubMed37310811

2023

Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs.

Applications

Unspecified application

Species

Unspecified reactive species

Kelsey L Polak,Ilaria Tamagno,Neetha Parameswaran,Jacob Smigiel,E Ricky Chan,Xueer Yuan,Brenda Rios,Mark W Jackson

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-LZP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LZP antibody (AB232686)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LZP antibody (AB232686)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LZP antibody (AB232686)

Western blot - Anti-LZP antibody (AB232686)

Western blot - Anti-LZP antibody (AB232686)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise