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AB198249

Anti-MAFF antibody

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(1 출판물)

Rabbit Polyclonal MAFF antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MAFF.

대체 명칭 보기

Transcription factor MafF, U-Maf, V-maf musculoaponeurotic fibrosarcoma oncogene homolog F, MAFF

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAFF antibody (AB198249)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAFF antibody (AB198249)

Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue labeling MAFF with ab198249 at 1/20 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAFF antibody (AB198249)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAFF antibody (AB198249)

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling MAFF with ab198249 at 1/20 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human MAFF. The exact immunogen used to generate this antibody is proprietary information.

Q9ULX9

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대체품

Primary Antibodies

AB227721

Anti-MAFF antibody - N-terminal

  • 0
  • 0
Primary Antibodies

AB183859

Anti-MAFF antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAFF antibody (AB183859)

  • 0
  • 0

보완 제품

Primary Antibodies

AB229766

Anti-MAFK antibody

Immunoprecipitation - Anti-MAFK antibody (AB229766)

  • 0
  • 0
Primary Antibodies

AB202083

Anti-Alanine Transaminase antibody [EPR19616]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Alanine Transaminase antibody [EPR19616] (AB202083)

  • 1
  • 1
Primary Antibodies

AB154318

Anti-MAFG antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAFG antibody (AB154318)

  • 0
  • 0
Primary Antibodies

AB137550

Anti-Nrf2 antibody

KO Validated

Western blot - Anti-Nrf2 antibody (AB137550)

  • 4
  • 7
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/100", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein MAFF also known as v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F functions as a transcription factor. It is a small protein with a molecular mass of approximately 18 kDa. MAFF is expressed in various tissues including the brain liver and pancreas. It belongs to the small Maf family characterized by their lack of transcriptional activation domains necessitating dimerization with other proteins to regulate gene expression.
Biological function summary

The small Maf protein MAFF plays an important role in regulating oxidative stress response and the coordinated expression of genes involved in detoxification processes. When part of a complex it often dimerizes with Nrf2 a protein that activates the expression of antioxidant response elements (ARE) in gene promoters. This kind of dimerization enables MAFF to indirectly regulate the transcription of genes involved in the cellular protection against oxidative damage.

Pathways

MAFF integrates into the antioxidant defense mechanism especially through its interaction with the Nrf2-Keap1 signaling pathway. Within this pathway MAFF through its interaction with Nrf2 facilitates the induction of cytoprotective genes that help in detoxification and maintaining cellular redox homeostasis. The interaction between MAFF and Nrf2 is significant as Nrf2 becomes stabilized and translocates to the nucleus under oxidative stress which is key for the pathway's protective effects.

MAFF through its interaction mainly with Nrf2 is associated with conditions like cancer and neurodegenerative diseases. In cancer the deregulation of the Nrf2 pathway often involving MAFF can lead to resistance against chemotherapy due to enhanced cellular antioxidant defenses therefore promoting tumor survival. Additionally in neurodegenerative disorders the inefficient activation of the MAFF-Nrf2 pathway may contribute to the accumulation of oxidative damage an underlying factor in diseases like Alzheimer's.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed : 8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed : 16549056, PubMed : 8932385). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed : 10527846).
See full target information MAFF
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Heliyon 10:e30603 PubMed38726149

2024

Tumor suppressor function of RBMS3 overexpression in EOC associated with immune cell infiltration.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Yin,Ying Zhang,Yue Zhao,Xinyi Zhang,Shuqi Han,Yixiao Wang,Bo Yang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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