AB84422

Anti-Matrin 3 antibody

5

(2 리뷰들)

|

(6 제품이 사용된 논문 )

Rabbit Polyclonal Matrin 3 antibody. Suitable for IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human MATR3 aa 800 to C-terminus.

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (AB84422)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (AB84422)

Detection of Human Matrin 3 by Immunofluorescence.

Sample : FFPE section of human breast carcinoma.
Antibody : ab84422 used at a dilution of 1/100.
Detection : Red-fluorescent Alexa Fluor 555 goat anti-rabbit IgG used at a dilution of 1/500.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (AB84422)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (AB84422)

Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human colon adenocarcinoma using 1/250 ab84422, followed by DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (AB84422)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (AB84422)

Detection of Human Matrin 3 by Immunofluorescence.

Sample : FFPE section of Human breast carcinoma.
Antibody : ab84422 used at a dilution of 1/100.
Detection : Red-fluorescent Alexa Fluor 555 goat anti-rabbit IgG used at a dilution of 1/500.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (AB84422)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (AB84422)

Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse squamous cell carcinoma using 1/250 ab84422, followed by DAB staining.

Immunocytochemistry/ Immunofluorescence - Anti-Matrin 3 antibody (AB84422)

ICC/IF

AbReview26054****

Immunocytochemistry/ Immunofluorescence - Anti-Matrin 3 antibody (AB84422)

ab84422 staining Matrin 3 in human U2OS cells by Immunocytochemistry/ Immunofluorescence.

Cells were fixed in paraformaldehyde, permeabilized using 0.5% NP-40, blocked with 1% BSA for 1 hour a room temperature, then incubated with ab84422 at a 1/100 dilution for 1 hour. The secondary antibody used was an Alexa-Fluor 488 conjugate donkey polyclonal, used at a 1/1000 dilution.

Image courtesy of Leilani Beltran by Abreview.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, ICC/IF

Immunogen

Synthetic Peptide within Human MATR3 aa 800 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

style

left-column

대체품

Primary Antibodies

AB151714

Anti-Matrin 3 antibody [EPR10635(B)]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Matrin 3 antibody [EPR10635(B)] (AB151714)

4
5

Primary Antibodies

AB70336

Anti-Matrin 3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody (AB70336)

5
1

Primary Antibodies

AB204295

Alexa Fluor® 488 Anti-Matrin 3 antibody [EPR10635(B)]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-Matrin 3 antibody [EPR10635(B)] (AB204295)

0
0

Primary Antibodies

AB151739

Anti-Matrin 3 antibody [EPR10634(B)]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Matrin 3 antibody [EPR10634(B)] (AB151739)

5
3

Primary Antibodies

AB240123

Anti-Matrin 3 antibody [EPR10635(B)] - BSA and Azide free

RabMAb|KO Validated|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Matrin 3 antibody [EPR10635(B)] - BSA and Azide free (AB240123)

0
0

보완 제품

Primary Antibodies

AB191881

Anti-Lin28B antibody [EPR18717]

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-Lin28B antibody [EPR18717] (AB191881)

0
0

Primary Antibodies

AB56783

Anti-TOMM20 antibody [4F3] - BSA and Azide free

Immunocytochemistry/ Immunofluorescence - Anti-TOMM20 antibody [4F3] - BSA and Azide free (AB56783)

4
23

Primary Antibodies

AB177487

Anti-NeuN antibody [EPR12763] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Frozen sections) - Anti-NeuN antibody [EPR12763] - Neuronal Marker (AB177487)

5
76

Primary Antibodies

AB140595

Anti-TIA1 antibody [EPR9304]

KO Validated|RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-TIA1 antibody [EPR9304] (AB140595)

2
1

style

left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>Note: expected to work on frozen sections.</p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>Note: expected to work on frozen sections.</p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Bat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chinese hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rhesus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

style

left-column

style

left-column

특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

+4°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

style

left-column

style

left-column

style

left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

타겟 정보

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed : 28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed : 32245947). May bind to specific miRNA hairpins (PubMed : 28431233).

See full target information MATR3

대체 명칭 보기

KIAA0723, MATR3, Matrin-3

style

left-column

제품이 사용된 논문 (6)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Biology 11: PubMed35205163

2022

Selective Loss of MATR3 in Spinal Interneurons, Upper Motor Neurons and Hippocampal CA1 Neurons in a MATR3 S85C Knock-In Mouse Model of Amyotrophic Lateral Sclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Justin You,Katarina Maksimovic,Jooyun Lee,Mashiat Khan,Rintaro Masuda,Jeehye Park

Nature communications 12:6241 PubMed34716321

2021

Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture.

Applications

Unspecified application

Species

Unspecified reactive species

Hye Ji Cha,Özgün Uyan,Yan Kai,Tianxin Liu,Qian Zhu,Zuzana Tothova,Giovanni A Botten,Jian Xu,Guo-Cheng Yuan,Job Dekker,Stuart H Orkin

Acta neuropathologica communications 8:177 PubMed33129345

2020

RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3.

Applications

Unspecified application

Species

Unspecified reactive species

Nandini Ramesh,Elizabeth L Daley,Amanda M Gleixner,Jacob R Mann,Sukhleen Kour,Darilang Mawrie,Eric N Anderson,Julia Kofler,Christopher J Donnelly,Evangelos Kiskinis,Udai Bhan Pandey

Nature communications 11:5304 PubMed33082323

2020

Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS.

Applications

Unspecified application

Species

Unspecified reactive species

Ching Serena Kao,Rebekah van Bruggen,Jihye Rachel Kim,Xiao Xiao Lily Chen,Cadia Chan,Jooyun Lee,Woo In Cho,Melody Zhao,Claudia Arndt,Katarina Maksimovic,Mashiat Khan,Qiumin Tan,Michael D Wilson,Jeehye Park

FEBS letters 594:2800-2818 PubMed32515490

2020

Knockdown of genes involved in axonal transport enhances the toxicity of human neuromuscular disease-linked MATR3 mutations in Drosophila.

Applications

Unspecified application

Species

Unspecified reactive species

Melody Zhao,Ching Serena Kao,Claudia Arndt,David Duc Tran,Woo In Cho,Katarina Maksimovic,Xiao Xiao Lily Chen,Mashiat Khan,Hongxian Zhu,Julia Qiao,Kailong Peng,Jingyao Hong,Jialu Xu,Deanna Kim,Jihye Rachel Kim,Jooyun Lee,Rebekah van Bruggen,Wan Hee Yoon,Jeehye Park

Molecular biology of the cell 27:3894-3902 PubMed27733621

2016

Identification of novel nesprin-1 binding partners and cytoplasmic matrin-3 in processing bodies.

Applications

ICC/IF, WB

Species

Human, Human

Dipen Rajgor,Jonathan G Hanley,Catherine M Shanahan

제품이 사용된 논문 모두 보기

style

left-column

style

left-column

style

right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com