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AB9700

Anti-MAX antibody

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(2 제품이 사용된 논문 )

Goat Polyclonal MAX antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MAX aa 100-200.
1 이미지
Western blot - Anti-MAX antibody (AB9700)
  • WB

Supplier Data

Western blot - Anti-MAX antibody (AB9700)

Primary incubation for 1 hour. Detected using chemiluminescence.

All lanes:

Western blot - Anti-MAX antibody (ab9700) at 0.01 µg/mL

All lanes:

Jurkat cell lysate in RIPA buffer at 35 µg

Predicted band size: 18 kDa

Observed band size: 22 kDa

false

주요 정보

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human MAX aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

P61244

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대체품

Primary Antibodies

AB53570

Anti-MAX antibody [73C5a]

Flow Cytometry - Anti-MAX antibody [73C5a] (AB53570)

  • 3
  • 1
Primary Antibodies

AB210819

Anti-MAX (phospho S11) antibody

Immunocytochemistry/ Immunofluorescence - Anti-MAX (phospho S11) antibody (AB210819)

  • 0
  • 0
Primary Antibodies

AB101271

Anti-MAX antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAX antibody (AB101271)

  • 0
  • 0
Primary Antibodies

AB199489

Anti-MAX antibody [EPR19352] - ChIP Grade

20ul selling size|RabMAb|Advanced Validation|Recombinant

ChIP-sequencing - Anti-MAX antibody [EPR19352] - ChIP Grade (AB199489)

  • 5
  • 3
Primary Antibodies

AB236028

Anti-MAX antibody [EPR19352] - ChIP Grade - BSA and Azide free

RabMAb|Advanced Validation|Recombinant

Immunoprecipitation - Anti-MAX antibody [EPR19352] - ChIP Grade - BSA and Azide free (AB236028)

  • 0
  • 0
Primary Antibodies

AB227298

Anti-MAX antibody

Immunoprecipitation - Anti-MAX antibody (AB227298)

  • 0
  • 0

보완 제품

Primary Antibodies

AB32072

Anti-c-Myc antibody [Y69] - ChIP Grade

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Myc antibody [Y69] - ChIP Grade (AB32072)

  • 4
  • 56
Primary Antibodies

AB210819

Anti-MAX (phospho S11) antibody

Immunocytochemistry/ Immunofluorescence - Anti-MAX (phospho S11) antibody (AB210819)

  • 0
  • 0
Primary Antibodies

AB185656

Anti-c-Myc (phospho S62) antibody [EPR17924]

RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Flow Cytometry (Intracellular) - Anti-c-Myc (phospho S62) antibody [EPR17924] (AB185656)

  • 0
  • 0
Primary Antibodies

AB1791

Anti-Histone H3 antibody - Nuclear Marker and ChIP Grade

Lab Essentials

ChIP - Anti-Histone H3 antibody - Nuclear Marker and ChIP Grade (AB1791)

  • 5
  • 233
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.01-0.03 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 0.5% BSA, 0.5% Tris
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The MAX protein also known as Myc-associated factor X functions mechanically as a transcription factor with a molecular weight of approximately 20 kDa. MAX is expressed in a wide range of tissues throughout the body. The protein forms homodimers or heterodimers with other members of the basic-helix-loop-helix-zipper (bHLHZ) family such as MYC MAD and MNT. The dimerization with different partners determines its role as an activator or repressor of transcription affecting the regulation of various genes.
Biological function summary

The MAX protein plays a significant role in controlling cell growth differentiation and apoptosis. The protein often forms part of complex regulatory networks within the cell. By interacting with different partner proteins MAX modulates transcriptional activity affecting cellular outcomes. Importantly it can switch between activating or repressing target genes depending on the dimer partner influencing processes such as proliferation and differentiation.

Pathways

MAX is deeply integrated into the MYC-MAX-MAD pathway an important pathway for regulating gene expression linked to cell cycle and proliferative processes. Within this pathway MAX pairs with either MYC or MAD depending on the cellular context to influence transcription. When paired with MYC it promotes transcription while pairing with MAD results in transcriptional repression. Additionally in the growth signaling pathway the MAX protein’s regulation of target genes is pivotal for ensuring proper cellular responses to growth signals.

The malfunction of the MAX protein has a strong association with cancer and neurodegenerative diseases. Alterations in MAX function can lead to uncontrolled cell growth contributing to oncogenesis particularly in relation to MYC which is a known oncogene. Furthermore dysregulation of the MAX protein is linked to neurodegenerative disorders where abnormal MAX activity may disrupt normal neural gene expression enhancing disease progression.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC : MAX complex is a transcriptional activator, whereas the MAD : MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.
See full target information MAX

대체 명칭 보기

BHLHD4, MAX, Protein max, Class D basic helix-loop-helix protein 4, Myc-associated factor X, bHLHd4
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in oncology 10:537763 PubMed33251130

2020

Long Non-Coding RNA MEG3 Modifies Cell-Cycle, Migration, Invasion, and Proliferation Through AKAP12 by Sponging miR-29c in Meningioma Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Chenyu Ding,Xuehan Yi,Jiaheng Xu,Zhenhua Huang,Xingyao Bu,Desheng Wang,Hongliang Ge,Gaoqi Zhang,Jianjun Gu,Dezhi Kang,Xiyue Wu

Cell chemical biology 26:711-723.e14 PubMed30880155

2019

Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Nicholas B Struntz,Andrew Chen,Anja Deutzmann,Robert M Wilson,Eric Stefan,Helen L Evans,Maricela A Ramirez,Tong Liang,Francisco Caballero,Mattheus H E Wildschut,Dylan V Neel,David B Freeman,Marius S Pop,Marie McConkey,Sandrine Muller,Brice H Curtin,Hanna Tseng,Kristen R Frombach,Vincent L Butty,Stuart S Levine,Clementine Feau,Sarah Elmiligy,Jiyoung A Hong,Timothy A Lewis,Amedeo Vetere,Paul A Clemons,Scott E Malstrom,Benjamin L Ebert,Charles Y Lin,Dean W Felsher,Angela N Koehler
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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