Anti-MCEE antibody [OTI1B5]

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Biological function summary

Methylmalonyl-CoA epimerase contributes to the metabolism by facilitating the reversible epimerization process of methylmalonyl-CoA. MCEE is part of an enzymatic complex alongside methylmalonyl-CoA mutase which further processes the epimerized product to succinyl-CoA. This pathway is important for the breakdown and utilization of odd-chain fatty acids and certain branched-chain amino acids feeding into the citric acid cycle which is a critical pathway for cellular energy production.

Pathways

Methylmalonyl-CoA epimerase finds its place in the catabolism of β-oxidation and is directly involved in the propionic acid pathway. This positions MCEE as an integral part in facilitating the conversion of lipids and branched-chain amino acids into energy. It works closely with methylmalonyl-CoA mutase which acts downstream linking MCEE to broader metabolic processes and ensuring the continuation of energy supply within the metabolic network. This relationship is important for maintaining cellular homeostasis particularly in energy-demanding tissues.